美罗培南联合人免疫球蛋白对化脓性脑膜炎的效果评价

Evaluation of the Effect of Meropenem Combined With Human Immunoglobulin on Purulent Meningitis

目的探讨美罗培南联合人免疫球蛋白治疗化脓性脑膜炎的效果。方法选择本院27例2014年4月—2019年3月化脓性脑膜炎患儿,采用随机数字表法分为两组,单一治疗组(n=12)采取常规药物治疗,联合治疗组(n=15)则采取常规药物、美罗培南联合人免疫球蛋白治疗,比较两组疗效、体温恢复正常时间、惊厥症状消失时间、脑脊液恢复正常时间、住院时间及病死率。结果联合治疗组治疗总有效率高于单一治疗组,差异有统计学意义(P <0.05);联合治疗组患儿体温恢复正常时间、惊厥症状消失时间、脑脊液恢复正常时间、住院时间均短于单一治疗组,差异均有统计学意义(P <0.05);联合治疗组患儿病死率低于单一治疗组,但差异无统计学意义(P> 0.05)。结论常规药物、美罗培南联合人免疫球蛋白治疗化脓性脑膜炎效果确切,可有效改善患儿的病情,控制炎症,控制惊厥发作,并可缩短治疗的时间和降低病死率,值得推广和应用。

Objective To investigate the efficacy of meropenem combined with human immunoglobulin in the treatment of purulent meningitis.Methods Twenty-seven children with purulent meningitis in our hospital from April 2014 to March 2019 were selected and divided into two groups by random number table method.The single treatment group(n=12)was treated with conventional drugs,and the combined treatment group(n=15)was treated with conventional drugs and meropenem combined with human immunoglobulin.The curative effect,time for body temperature to return to normal,time for the convulsive symptoms to disappear,time for cerebrospinal fluid to return to normal,the length of hospital stay and mortality were compared between the two groups.Results The total effective rate in the combined treatment group was significantly higher than that in the single treatment group,and the difference was statistically significant(P<0.05).The time for body temperature to return to normal,the time for convulsive symptoms to disappear,the time for cerebrospinal fluid to return to normal,and the hospitalization time in the combined treatment group were significantly shorter than those in the single treatment group(P<0.05).The mortality of children in the combined treatment group was lower than that in the single treatment group,but the difference was not statistically significant(P>0.05).Conclusion Conventional drugs and meropenem combined with human immunoglobulin are effective in the treatment of purulent meningitis,which can effectively improve the condition of children,control inflammation,control convulsion,shorten the time of treatment and reduce mortality,which is worth popularizing and applying.