养心益阳汤对慢性心力衰竭患者IL-6、IL-18、hs-CRP水平的影响

Influence of Heart-nourishing Yang-invigorating Decoction on the Levels of IL-6,IL-18 and hs-CRP in CHF Patients

目的:观察养心益阳汤治疗慢性心力衰竭的临床疗效及对患者白细胞介素6(interleukin-6,IL-6)、白细胞介素18(interleukin-18,IL-18)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平的影响。方法:将95例患者按入院顺序分为两组。对照组48例,给予利尿剂、强心苷、血管扩张剂等常规西医治疗,同时给予美托洛尔进行治疗;观察组47例,在对照组治疗基础上服用养心益阳汤,两组均治疗3个月。对比两组临床疗效、心肺功能指标和炎症因子水平。结果:总有效率观察组为89.4%(42/47),对照组为60.4%(29/48),两组比较差异有统计学意义(P<0.05)。用力肺活量(forced vital capacity,FVC)、一秒钟用力呼气容积(first second forced vital capacity,FEV1)、左心室射血分数(left ventricular ejec-tion fraction,LVEF)、脑尿钠肽(brain natriuretic peptide,BNP)水平治疗前两组比较,差异无统计学意义(P>0.05),两组治疗后FVC、FEV1、左室EF值两组均显著升高(P<0.05),BNP水平两组均明显降低(P<0.05),且观察组更为显著(P<0.05)。IL-6、IL-18、hs-CRP水平治疗前两组比较,差异无统计学意义(P>0.05);治疗后两组均显著降低(P<0.05),且观察组降低更为显著(P<0.05)。结论:养心益阳汤治疗慢性心力衰竭临床疗效显著,其可有效改善患者的心肺功能指标,并调节其炎症因子水平。

Objective:To observe clinical effects of heart-nourishing yang-invigorating decoction(HY)in the treatment for chronic heart failure(CHF)and its influence on the levels of IL-6,IL-18 and hs-CRP.Methods:All 95 patients were allocated to two groups according to admission order.48 cases of the control group were given Western medicine therapy including diuretics,cardiac glycoside,vasodilator and others,meanwhile,metoprolol;47 cases of the observation group took HY,both groups were treated for three months.To compare clinical effects,the indexes of cardiac and pulmonary function and the levels of inflammatory factors.Results:Total effective rate of the observation group reached 89.4%(42/47),higher than 60.4%(29/48)of the control group,and the difference showed statistical meaning between both groups(P<0.05).There was no obvious difference in the levels of FVC,FEV1,LVEF and BNP between both groups before treating(P>0.05);after treating,FVC,FEV1 and LVEF of both groups rose(P<0.05),BNP level lowered notably in both groups(P<0.05),and the improvements of the observation group were more notable(P<0.05).There was no obvious difference in the levels of IL-6,IL-18 and hs-CRP before treating between both groups(P>0.05);after treating these reduced notably in both groups(P<0.05),the decrease of the observation group was more notable(P<0.05).Conclusion:Heart-nourishing yang-invigorating decoction in the treatment for CHF could gain notable clinical effects,and it could effectively improve the indexes of cardiac and pulmonary function,and regulate the levels of inflammatory factors.