益气通络饮联合西医基础方案治疗急性脑梗死疗效观察

Clinical Observation on Qi-invigorating Collateral-dredging Drink Combined with Western Medicine Basic Regimen in the Treatment for Acute Cerebral Infarction

目的:观察益气通络饮联合西医基础干预方案治疗急性脑梗死临床疗效。方法:将急性脑梗死患者96例采用随机数字表法分为对照组和试验组各48例,对照组给予西医基础干预,试验组在此基础上加用益气通络饮;治疗14天后观察两组患者临床疗效、治疗前后中医证候积分、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分及Barthel指数(Barthel index,BI)评分、血液流变学、血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管生成素1(Angiopoietin-1,Ang-1)及碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)水平。结果:试验组总有效率为93.8%(45/48),高于对照组的79.2%(38/48)(P<0.05);试验组治疗后中医证候积分、NIHSS评分、血浆黏度(plasma viscosity,PV)、纤维蛋白原(fibrinogen,FIB)及红细胞压积(haematocrit,Hct)水平均低于对照组及治疗前(P<0.05),BI高于对照组及治疗前(P<0.05);同时试验组治疗后VEGF、Ang-1及bFGF水平均高于对照组及治疗前(P<0.05)。结论:益气通络饮联合西医基础干预方案可减轻急性脑梗死患者神经功能损伤,改善生活质量,降低血液黏稠度,并有助于调节VEGF、Ang-1及bFGF水平。

Objective:To observe clinical effects of Qi-invigorating collateral-dredging drink and Western medicine basic regimen in the treatment for acute cerebral infarction.Methods:All 96 patients were allocated to the control group and the experiment group in light of random number table method,48 cases each group,the control group was given Western medicine basic regimen,and the experiment group took Qi-invigorating collateral-dredging drink;after treating for 14 days to observe curative effects of both groups,TCM syndrome scores,NIHSS and BI scores,hemorheology,the levels of VEGF,Ang-1 and bFGF before and after treating.Results:Total effective rate of the experiment group was 93.8%(45/48),higher than 79.2%(38/48)of the control group(P<0.05);the experiment group after treating was lower than the control group and before treating in TCM syndrome scores and NIHSS,the levels of PV,FIB and Hct(P<0.05);higher than the control group and the experiment group before treating in BI(P<0.05),simultaneously,the experiment group after treating was higher than the control group and before treating in the levels of VEGF,Ang-1 and bFGF(P<0.05).Conclusion:Qi-invigorating collateral-dredging drink and Western medicine basic regimen in the treatment for acute cerebral infarction could alleviate neurological function damage,improve quality of life,decrease blood viscoity,and it is helpful to regulate the levels of VEGF,Ang-1 and bFGF.