滋阴补气祛瘀饮联合西药对ACA阳性反复自然流产患者的影响

Effects of Yin-nourishing Qi-invigorating Stagnation-eliminating Drink Combined with Western Medicine on the Patients with Positive-ACA Recurrent Spontaneous Abortion

目的:探讨滋阴补气祛瘀饮联合西药对抗心磷脂抗体(anticardiolipin antibody,ACA)阳性反复自然流产患者疗效及性激素水平的影响。方法:将ACA阳性反复自然流产患者80例按随机数字表法分为对照组和观察组各40例,对照组患者口服阿司匹林100 mg,每日1次,同时肌肉注射绒毛膜促性腺性激素每次2000 U,每日1次,观察组在对照组治疗的基础上加用滋阴补气祛瘀饮,治疗3个月后比较两组患者近期疗效、ACA转阴率、远期妊娠率,治疗前后中医证候积分、子宫动脉血流参数指标及性激素水平。结果:观察组总有效率、ACA转阴率及远期妊娠率均高于对照组(P<0.05);观察组治疗后中医证候评分低于对照组及治疗前(P<0.05);观察组治疗后子宫动脉血流收缩期峰值流速(peak systolic velocity,PSV)、舒张末期血流速度(end diastolic velocity,EDV)水平均高于对照组及治疗前(P<0.05),阻力指数(resistance index,RI)水平低于对照组及治疗前(P<0.05);观察组治疗后人绒毛膜促性腺性激素(human chorionic gonadotropin,HCG)、孕酮(progesterone,P)及雌二醇(estradiol,E2)水平均高于对照组及治疗前(P<0.05)。结论:滋阴补气祛瘀饮联合西药可有效缓解ACA阳性反复自然流产患者临床症状,提高远期妊娠率,促进ACA转阴,改善子宫动脉血流参数,并有助于调节性激素水平。

Objective:To explore the effects of Yin-nourishing Qi-invigorating stagnation-eliminating drink combined with Western medicine on clinical effects and sex hormone level of the patients with positive-ACA recur-rent spontaneous abortion(RSA).Methods:Eighty patients were divided into the control group and the observation group according to random number table method,40 cases each group,the control group took aspirin orally,100mg,once each day;muscular injection of human chorionic gonadotropin(HCG),2000 U each time,once each day,the observation group took Yin-nourishing Qi-invigorating stagnation-eliminating drink,to compare short-term effects,ACA negative conversion rate,long-term pregnancy rate,TCM syndrome scores before and after treating,uterine artery blood flow parameters and sex hormone level between both groups after treating for five days.Results:The observation group was higher than the control group in total effective rate,ACA negative conversion rate and long-term pregnancy rate(P<0.05);TCM syndrome scores of the observation group after treating were lower than these of the control group and the observation group before treating(P<0.05);the observation group after treating was higher than the control group and the observation group before treating in PSV and EDV levels(P<0.05),lower than the control group and the observation group before treating in RI levels(P<0.05);HCG,P and E2 levels of the observation group after treating were higher than these of the control group and the observation group before treating(P<0.05).Conclusion:Yin-nourishing Qi-invigorating stagnation-eliminating drink combined with Western medicine could effectively relieve clinical symptoms of the patients,raise long-term pregnancy rate,promote ACA negative conversion and improve uterine artery blood flow parameters and it is helpful to regulate sex hormone levels.