儿童难治性细菌性脑膜炎研究进展

Study progress of refractory bacterial meningitis in children

难治性细菌性脑膜炎目前暂无明确定义,其临床意义是指治疗过程曲折、疗效差、或病情反复或出现并发症,预后差或以死亡为结局的细菌性脑膜炎。该病的发病相关因素包括诊治不及时、病情重、病原学阳性、发生并发症或存在原发疾病。早期合理使用抗生素,正确使用激素,积极处理并发症,同时重视查找和去除难治性细菌性脑膜炎病因,对缩短病程及改善预后有重要意义。

Refractory bacterial meningitis is not clearly defined.Its clinical significance refers to the tortuosity,poor efficacy,or repeated or complications of partial bacterial meningitis,poor prognosis,and even death.Factors associa-ted with the onset of the disease include delays untimely diagnosis and treatment,severe illness,positive pathogens,complications,or presence of primary disease.It will be significant for improving prognosis and shortening the course through early rational use of antibiotics,appropriate choose of glucocorticoid,active treatment of complications,attention to searching and removing the cause.