摘要
N6甲基腺嘌呤(m^6A) 修饰是最常见的丰富而保守的转录后修饰,越来越多的证据提示m^6A修饰通过各种机制对肝癌、胃癌、肺癌、膀胱癌和黑色瘤等肿瘤产生一定的影响。研究发现YT521-B同源结构域家族蛋白1(YTHDF1)作为m^6A修饰的结合蛋白,对肿瘤的转录、翻译、蛋白质合成、免疫逃逸、上皮间充质转化(EMT)、化疗耐药等方面起重要作用。揭示YTHDF1的作用机制,有望为癌症诊治找到新的方法。本文就此方面的研究进展进行综述。
N6-methyladenosine(m^6A)modification is the most common,abundant and conservative posttranscriptional modification.More and more evidence suggest that via various mechanisms,it has a certain impact on tumors,such as liver cancer,gastric cancer,lung cancer,bladder cancer and melanoma.It has been found that YTHDF1,as a kind of m^6A-modification binding protein,plays an important role in tumor transcription,translation,protein synthesis,immune escape,EMT,chemotherapy resistance and so on.It is expected to find new methods for the diagnosis and treatment of cancer by revealing the mechanism of YTHDF1.This article reviews the research progress in this field.
作者
肖世伟
王海峰
王剑松
丁明霞
XIAO Shiwei;WANG Haifeng;WANG Jiansong;DING Mingxia(Department of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Urology,Guizhou Provincial People’s Hospital,Guiyang 550002,China)
出处
《肿瘤防治研究》
CAS
CSCD
2020年第9期712-715,共4页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(81660422)
贵州省卫生健康委科学技术基金(gzwjkj2019-1-130)。
