摘要
随着人口老龄化及动脉粥样硬化性心血管疾病(arteriosclerotic cardiovascular disease,ASCVD)发病率的提高,心力衰竭的患病率逐年增加。射血分数保留心力衰竭(heart failure preserved ejection fraction,HFpEF)是其中重要的分型,而2型糖尿病(type 2 diabetes mellitus,T2DM)是导致HFpEF的重要病因之一。本综述通过回顾临床指南和临床研究中HFpEF的诊断要点,从人口学特征、心血管病预后和全因死亡率等不同角度,对比大型流行病学研究中HFpEF与射血分数受损心力衰竭(heart failure reduced ejection fraction,HFrEF)的差异;同时,全面描述并分析HFpEF合并T2DM的临床特征、流行病学表现、发病机制及预后表现。
Because of the aging of population and elevated incidence of arteriosclerotic cardiovascular disease(ASCVD),the prevalence of heart failure is increasing steadily in recent decades.Heart failure preserved ejection fraction(HFpEF)is one of the most important types,and type 2 diabetes mellitus(T2DM)is one of the particular important etiologies.We distinguished the differences of patients’characteristics,diagnosis and prognosis,and all-cause mortality in HFpEF from heart failure reduced ejection fraction(HFrEF)through guidelines and clinical randomized trails.Meantime,we comprehensively described and analyzed the clinical feature,epidemic characteristics,mechanism,and prognosis of T2DM comorbid with HFpEF in this review.
作者
包丽雯(综述)
刘荣宸
严芳英
谢坤
金波
高秀芳
李剑
施海明
李勇(审校)
BAO Li-wen;LIU Rong-chen;YAN Fang-ying;XIE Kun;JIN Bo;GAO Xiu-fang;LI Jian;SHI Hai-ming;LI Yong(Department of Cardiovascular Disease,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《复旦学报(医学版)》
CAS
CSCD
北大核心
2020年第5期789-794,共6页
Fudan University Journal of Medical Sciences
基金
科技部“重大新药创制”科技重大专项(2017ZX09304005)
复旦大学附属华山医院科研启动基金(2020QD009)。