射血分数保留心力衰竭与2型糖尿病的研究进展

Progression on heart failure preserved ejection fraction and type 2 diabetes mellitus

随着人口老龄化及动脉粥样硬化性心血管疾病(arteriosclerotic cardiovascular disease,ASCVD)发病率的提高,心力衰竭的患病率逐年增加。射血分数保留心力衰竭(heart failure preserved ejection fraction,HFpEF)是其中重要的分型,而2型糖尿病(type 2 diabetes mellitus,T2DM)是导致HFpEF的重要病因之一。本综述通过回顾临床指南和临床研究中HFpEF的诊断要点,从人口学特征、心血管病预后和全因死亡率等不同角度,对比大型流行病学研究中HFpEF与射血分数受损心力衰竭(heart failure reduced ejection fraction,HFrEF)的差异;同时,全面描述并分析HFpEF合并T2DM的临床特征、流行病学表现、发病机制及预后表现。

Because of the aging of population and elevated incidence of arteriosclerotic cardiovascular disease(ASCVD),the prevalence of heart failure is increasing steadily in recent decades.Heart failure preserved ejection fraction(HFpEF)is one of the most important types,and type 2 diabetes mellitus(T2DM)is one of the particular important etiologies.We distinguished the differences of patients’characteristics,diagnosis and prognosis,and all-cause mortality in HFpEF from heart failure reduced ejection fraction(HFrEF)through guidelines and clinical randomized trails.Meantime,we comprehensively described and analyzed the clinical feature,epidemic characteristics,mechanism,and prognosis of T2DM comorbid with HFpEF in this review.