前额叶在慢性疼痛非药物治疗中的神经调控作用及机制

The neural modulation effect of prefrontal cortex and related mechanism in non-pharmacological therapy of chronic pain

慢性疼痛是目前亟待解决的公共健康问题,临床常面临止痛药物治疗效果不佳或耐受度差等挑战。研究认为,慢性疼痛的发生发展涉及多个脑区的变化,中枢调控机制,尤其是前额叶皮质及其相关脑区在其中起到重要作用。慢性疼痛的非药物治疗,例如经颅直流电刺激、经颅重复磁刺激、认知行为疗法等,近年来逐渐成为极具潜力的有效治疗手段。文章将针对慢性疼痛非药物治疗的前额叶相关神经调控研究进展进行综述,关注这些治疗方法产生的脑结构和功能的变化,以进一步探索脑功能调控慢性疼痛的机制,为慢性疼痛非药物治疗的进一步优化提供理论依据。

Chronic pain is a public health concern of desiderate to be solved,and analgesics is not always successful and may be difficult to tolerate in clinic.Studies have suggested that the development of chronic pain involves alterations in multiple brain regions.Central modulation mechanisms,especially those soliciting the prefrontal cortex and its related brain regions,may play an important role.Non-pharmacological therapies such as transcranial direct current stimulation,transcranial repetitive magnetic stimulation and cognitive behavior therapy have emerged to be effective interventions of great potential for chronic pain in recent years.Hereby the research progress was reviewed on the neural modulation effect of prefrontal cortex in non-pharmacological treatment of chronic pain,focusing on the related changes in brain structure and function,to further explore the underlying mechanism of pain modulation,and provide theoretical basis to optimize non-pharmacological treatment of chronic pain.