基于数据挖掘的国医大师治疗痛风用药规律研究

Study on Medication Rules of TCM Masters in Gout Treatment Based on Data Mining

目的:深层次挖掘国医大师治疗痛风的用药规律。方法:在中国知网、万方医学网、维普数据库,系统全面搜集三届国医大师治疗痛风的处方,结合中医传承辅助平台V2.5进行用药规律研究数据挖掘。结果:共筛选出国医大师治疗痛风处方66张,高频药物包括当归、苍术、薏苡仁、黄柏等,归经多属肝经、脾经、胃经,高频组合包括"黄柏,苍术""苍术,薏苡仁""黄柏,薏苡仁"等,并得到1个新处方,即白术-附子-金樱子-猪苓-党参-熟地黄-蜈蚣。结论:国医大师治疗痛风用药以清热利湿泄浊,健脾补肾通络为主。

Objective:To deeply explore the medication rules of TCM masters in the treatment of gout.Methods:In CNKI,Wanfang Medical Network,VIP Database,formulas for gout treatment by three batches of TCM masters were collected systematically and comprehensively,and data mining was conducted based on the TCM inheritance auxiliary platform v2.5.Results:A total of 66 formulas were screened for gout treatment by the TCM masters.The high-frequency medicinals included Danggui(Radix Angelicae Sinensis),Cangzhu(Rhizoma Atractylodis),Yiyiren(Semen Coicis),Huangbai(Cortex Phellodendri Chinensis),etc.Most of meridian tropism belonged to the liver,spleen and stomach meridians.High frequency combinations included Huangbai-Cangzhu,Cangzhu-Yiyiren,Huangbai-Yiyiren,etc.A new formula was obtained,including Baizhu(Rhizoma Atractylodis Macrocephalae),Fuzi(Radix Aconiti Lateralis Preparata),Jinyingzi(Fructus Rosae Laevigatae),Zhuling(Polyporus),Dangshen(Radix Codonopsis),Shudihuang(Radix Rehmanniae Praeparata) and Wugong(Scolopendra).Conclusion:TCM masters mainly use the methods of clearing heat,draining dampness,purging turbid,invigorating spleen,tonifying kidney and dredging collaterals to treat gout.