降气活血方联合西药治疗急性加重期慢性阻塞性肺疾病痰浊阻肺证30例

Thirty Cases of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm Turbid Obstructing Lung Syndrome Treated with Decoction for Descending Qi and Promoting Blood Circulation in Combination with Integrated Traditional Chinese and Western

目的:观察降气活血方联合西药治疗急性加重期慢性阻塞性肺疾病(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)痰浊阻肺证的临床疗效。方法:将60例AECOPD痰浊阻肺证患者按照随机数字表法分为治疗组和对照组,每组30例。对照组采用西医常规治疗,治疗组在对照组的基础上联合降气活血方治疗。比较两组患者的临床疗效及治疗前后中医证候积分、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)水平、全血高切黏度等。结果:治疗组有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05)。两组患者治疗后咳嗽、痰质、痰量、喘息积分及总积分均较本组治疗前降低,且治疗组治疗后低于对照组治疗后,差异有统计学意义(P<0.05)。两组患者治疗后TNF-α、IL-6水平低于本组治疗前,IL-10水平高于本组治疗前,差异具有统计学意义(P<0.05);治疗组治疗后TNF-α水平低于对照组,IL-10水平高于对照组,差异有统计学差异(P<0.05)。治疗组全血高切黏度低于本组治疗前及对照组治疗后,差异具有统计学意义(P<0.05)。结论:降气活血方联合西药治疗AECOPD痰浊阻肺证,可明显改善患者临床症状,调节炎性介质,降低全血高切黏度。

Objective:To observe the clinical curative effect of Decoction for Descending Qi and Promoting Blood Circulation in combination with integrated traditional Chinese and Western medicine therapy on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm turbid obstructing lung syndrome.Methods:A total of 60 AECOPD patients with phlegm turbidity obstructing lung syndrome were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was treated with conventional western medicine,while the treatment group was additionally treated with Decoction for Descending Qi and Promoting Blood Circulation on the basis of the control group.The clinical efficacy,TCM syndrome score,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),blood viscosity,etc.were compared between the two groups before and after the treatment.Results:The effective rate of the treatment group was 96.67%,which was higher than 73.33% of the control group,and the difference was statistically significant(P<0.05).After the treatment,cough,sputum quality,sputum volume,wheezing score and total score of the two groups were lower than those before the treatment,and the above indexes of the treatment group were lower than those of the control group after the treatment,and all the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α and IL-6 in the two groups were lower than those of the same group before the treatment,while the level of IL-10 was higher than that of the same group before treatment,and all the differences were statistically significant(P<0.05).After the treatment,the level of TNF-α in the treatment group was lower than that in the control group,while the level of IL-10 in the treatment group was higher than that in the control group,and all the differences were statistically significant(P<0.05).The blood viscosity in the treatment group was lower than that of the same group before the treatment and that in the control group after the treatment,and all the differences were statistically significant(P<0.05).Conclusion:In terms of AECOPD with phlegm turbidity obstructing lung syndrome,Decoction for Descending Qi and Promoting Blood Circulation in combination with integrated traditional Chinese and Western medicine therapy can significantly improve the clinical symptoms of patients,regulate inflammatory mediators and reduce blood viscosity.