摘要
文章从物料性质、反应平衡、后处理操作和三废处理等方面对原料药工业化工艺进行了安全评估,并依据评估风险给出了相应防范建议。旨在提升从业人员安全意识,提高生产安全性,保障人员生命安全,最大限度降低财产损失。有效引导工艺研发者在工艺开发前期规避安全风险,开发更适合工业化生产的绿色环保工艺。
In this paper,the safety evaluation of the industrial process of APIs is carried out from the aspects of material properties,reaction balance,post-processing operations and three waste treatments,and corresponding preventive suggestions are given based on the assessment risks.This article aims to enhance the safety awareness of practitioners,improve production safety,ensure the safety of personnel’s lives,and minimize property losses.At the same time,it can effectively guide the process developers to avoid safety risks in the early stage of process development,and develop more suitable for industrial production of green and environmental protection process.
作者
戚郜飞
金爱民
杨文彬
刘乐鹏
徐士伟
QI Gao-fei;JIN Ai-min;YANG Wen-bin;LIU Le-peng;XU Shi-wei(Hansoh Pharmaceutical Co.,Ltd.,Lianyungang 222000,China)
出处
《化工管理》
2020年第28期47-48,共2页
Chemical Engineering Management
关键词
工业化工艺
安全评估
绿色环保
industrial process
safety evaluation
green and environmental protection process