乌司他丁治疗急性胰腺炎的有效性分析

Analysis of the Effectiveness of Ulinastatin in the Treatment of Acute Pancreatitis

目的分析乌司他丁治疗急性胰腺炎的有效性。方法 2017年9月—2019年4月,在该院接受治疗的AP患者里方便选取80例患者作为样本进行分析,所选取的患者没有严重的自身免疫性疾病等基础疾病。将所选取的患者随机分成对照组(常规治疗)、治疗组(常规治疗+乌司他丁治疗),每组患者各为40例,对比两组患者治疗半个月后生活质量评分、临床疗效等指标。结果治疗组治疗15 d,显效率+好转率为87.50%,高于对照组75.00%,差异有统计学意义(χ^2=6.491,P<0.05);治疗前,两组患者在心理功能、社会功能、躯体健康、环境功能等维度的生活质量评分具有相似性,差异有统计学意义(t=0.151、1.328、1.744、0.077,P=0.888、0.188、0.085、0.939),治疗后治疗组的各维度分值改善幅度更大,差异无统计学意义(t=17.530、12.011、12.524、8.664,P<0.05)。结论急性胰腺炎患者采用乌司他丁治疗方案,可以有效改善患者的疾病症状,促进患者病情转归,使患者在短时间内恢复健康生活,提高患者的预后水平。

Objective To analyze the effectiveness of Ulinastatin in the treatment of acute pancreatitis.Methods From September 2017 to April 2019,80 patients were convenient selected from AP patients treated in the hospital as samples for analysis.The selected patients did not have serious autoimmune diseases and other underlying diseases.The selected patients were randomly divided into a control group(conventional treatment)and a treatment group(conventional treatment+ulinastatin treatment).There were 40 patients in each group.The quality of life scores and clinical efficacy,and other indicators of the two groups were compared after half a month of treatment.Results The treatment group was treated for15 days,the marked efficiency+improvement rate was 87.50%,which was higher than the control group 75.00%,the difference was not statistically significant(χ~2=6.491,P<0.05);before treatment,the two groups of patients with psychological function,social function,physical health,environmental function and other dimensions of the quality of life scores were similar,the difference was statistically significant(t=0.151,1.328,1.744,0.077,P=0.888,0.188,0.085,0.939).After treatment,the scores of each dimension of the treatment group improved even more,the difference was statistically significant(t=17.530,12.011,12.524,8.664,P<0.05).Conclusion Ulinastatin treatment for patients with acute pancreatitis can effectively improve the symptoms of the patient’s disease,promote the outcome of the patient’s condition,enable the patient to return to a healthy life in a short time,and improve the patient’s prognosis.