植物乳杆菌CCFM8610对去卵巢大鼠骨质疏松症的改善作用

Ameliorative effects of Lactobacillus plantarum CCFM8610 on osteoporosis in ovariectomized rats

绝经后骨质疏松因雌激素缺乏会引起肠道菌群失调、肠道屏障受损、肠道通透性增加、宿主免疫力降低。目前治疗骨质疏松的药物长期使用大多具有较强的副作用,因此亟待寻求新的安全有效、长期干预的膳食途径。过往动物实验和临床试验表明,1株泡菜中分离得到的植物乳杆菌CCFM8610具有恢复肠道屏障损伤、调节肠道免疫系统、促进宿主细胞代谢等潜在功能,该研究旨在进一步探讨植物乳杆菌CCFM8610对骨质疏松症的改善作用。通过建立摘除双侧卵巢诱导骨质疏松的大鼠模型,证明植物乳杆菌CCFM8610可以显著改善去卵巢大鼠的骨结构指标,改善去卵巢大鼠骨代谢的高转换率;并调节肠道屏障,降低骨质疏松症大鼠血清炎症因子活性来抑制骨吸收。因此植物乳杆菌CCFM8610可通过增强肠道屏障功能和调节机体免疫系统有效缓解去卵巢大鼠骨质疏松症,为骨质疏松的防治开辟新路径。

Postmenopausal osteoporosis,due to its estrogen deficiency,may cause intestinal flora disorder,intestinal barrier damage,intestinal permeability increase and host immunity decrease.At present,most of the drugs used for long-term treatment of osteoporosis have strong side effects,so it is urgent to find a new safe,effective and long-term dietary intervention approach.Past animal experiments and clinical trials showed that Lactobacillus plantarum CCFM8610 isolated from pickle had the potential functions of restoring intestinal barrier damage,regulating intestinal immune system and promoting host cell metabolism.This study aimed to further explore the improvement of L.plantarum CCFM8610 on osteoporosis.By removing bilateral ovaries of rats to establish a postmenopausal osteoporosis model,it was proved that L.plantarum CCFM8610 could significantly improve the bone structure index and high bone metabolism rate of ovariectomized rats.It also regulated the intestinal barrier and reduced the activity of serum inflammatory cytokines to inhibit bone resorption in rats with osteoporosis.Therefore,L.plantarum CCFM8610 can effectively alleviate osteoporosis in ovariectomized rats by enhancing intestinal barrier function and regulating the body′s immune system,which opens a new path for the prevention and treatment of osteoporosis.