非侵入式眼表综合分析仪可无创性评估干眼患者的眼表情况

Noninvasive ocular surface analyzer evaluates non-aggressively the ocular surface of patients with dry eye disease

目的探讨非侵入式眼表综合分析仪用于评估干眼(DED)患者眼表情况的临床意义。方法DED患者50例(50只眼)作为DED组,健康志愿者50名(50只眼)作为对照组。依次进行病史询问、眼表疾病指数(OSDI)问卷调查;非侵入式眼表综合分析仪检查非侵入性首次泪膜破裂时间(NIBUTf)及睑板腺情况;裂隙灯显微镜观察睑缘、角膜荧光素染色(CFS)及泪膜破裂时间(FBUT)。结果DED组OSDI分值较对照组高(P<0.01);NIBUTf与FBUT呈正相关(均P<0.01);DED组NIBUTf和FBUT均较对照组低,而睑板腺缺失(MGL)评分和CFS均较对照组高(P<0.01);NIBUTf与OSDI及MGL评分均呈负相关(P<0.01)。结论非侵入式眼表综合分析仪可无创性检测泪膜稳定性和睑板腺缺失情况,对客观评估干眼患者的眼表情况具有重要临床意义。

Objective To evaluate the clinical use of noninvasive ocular surface analyzer in checking the ocular surface of dry eye disease(DED)patients.Methods A total of 100 eyes were covered in this study,in which 50 eyes were from DED patients(named DED group)and 50 eyes were from healthy volunteers(named control group).All subjects completed following examinations and tests:detailed medical history,ocular surface disease index(OSDI)questionnaire,the first noninvasive tear breakup time(NIBUTf)and morphological characteristics of meibomian glands examined by a noninvasive ocular surface analyzer,tear breakup time by fluorescein(FBUT),corneal fluorescein staining(CFS),the eyelid,and ocular surface organization checked by the slit lamp micros-cope.Results Compared with the control group,OSDI score of DED group was significantly higher(P<0.01).NIBUTf had a positive correlation with FBUT(P<0.01).The NIBUTf and FBUT were shorter,while the scores of meibomian gland loss(MGL)and CFS were higher in DED group(all P<0.01).NIBUTf had a negative correlation with MGL score and OSDI score(all P<0.01).All subjects accepted the examinations with signed the informed consent form,and the same examination was performed by the same inspector.Conclusions The non-inva-sive ocular surface analyzer may detect the tear film stability and meibomian gland loss by a non-contact way,and it has important clinical potential to evaluate the ocular surface of dry eye patients objectively.