食管腺癌细胞系及模型和3D培养的研究进展

Advances in the study of esophageal adenocarcinoma cell lines,model develpoment and 3D culture technology

食管腺癌是一种少见的恶性肿瘤。食管腺癌恶化和转移的性质为肿瘤的治疗带来了一定程度的困难和挑战。近年来,食管腺癌细胞系研究取得了一定程度的进展,但肿瘤细胞内微观分子水平的发生机制还有许多未被知晓,食管腺癌细胞间的差异性仍需要继续探索。食管腺癌细胞模型的建立和发展可用于研究肿瘤细胞性质和特点,各种肿瘤细胞模型为食管腺癌的发生机制提供了研究工具,有利于了解肿瘤细胞内基因的异常表达和微观信号分子对肿瘤增殖的影响因素。类器官的3D-培养能够为肿瘤细胞的异性质和微观水平表达的研究提供理想的平台,为推进对肿瘤细胞性质的研究提供了有利的条件。

Esophageal adenocarcinoma is a uncommon malignant tumor.The deterioration and metastasis of esophageal adenocarcinoma bring some difficulties and challenges to the treatment of tumor.In recent years,some progress has been made in the study of esophageal adenocarcinoma cell lines.However,there are still many unknown molecular mechanisms in tumor cells,and the differences between esophageal adenocarcinoma cells still need to be further explored.The establishment and development of esophageal adenocarcinoma cell model can be used to study the properties and characteristics of tumor cells,and various tumor cell models provide research tools for the mechanism of esophageal adenocarcinoma pathogenesis,which is conducive to understanding the abnormal expression of genes in tumor cells and the influence factors of microsignaling molecules on tumor proliferation.The 3D-culture of organoid can provide an ideal platform for the study of the heterogeneous properties and microscopic level expression of tumor cells,and provide favorable conditions for the advancement of the study of the properties of tumor cells.