脑蛋白水解物联合尤瑞克林治疗短暂性脑缺血发作的疗效及对神经功能脑血流动力学的影响

Effect of cerebrotein hydrolysate combined with urinary kallidinogenase in the treatment of transient ischemic attack and its influence on neurological function and cerebral hemodynamics

目的探讨脑蛋白水解物联合尤瑞克林治疗短暂性脑缺血发作(TIA)的临床疗效。方法采用随机数字表法,对2017年5月至2019年5月收治的102例TIA患者予以分组,对照组51例,采用常规治疗,观察组51例,加脑蛋白水解物联合尤瑞克林治疗,观察2组疗效、神经功能、脑血流动力学变化及不良反应情况。结果观察组治疗总有效率为94%,与对照组80%对比,差异有统计学意义(P<0.05);治疗前,2组各指标差异无统计学意义(P>0.05),观察组治疗8周后美国国立卫生研究院卒中量表(NHISS)、Barthel指数(BI)情况及双侧大脑中动脉平均血流速度(Vmean)、脑平均血流量(Qmean)、脑血管阻力(R)情况明显优于同期对照组(P<0.05)。结论TIA患者接受脑蛋白水解物联合尤瑞克林治疗,效果显著,神经功能及脑血流动力学可得到明显改善,值得推广。

Objective To investigate the clinical effect of cerebrotein hydrolysate combined with urinary kallidinogenase in the treatment of transient ischemic attack(TIA).Methods A total of 102 patients with TIA treated in our hospital between May 2017 and may 2019 were divided into the control group(n=51)and study group(n=51)by random number table.The control group was treated with routine therapy,and in addition to this,the study group was given cerebrotein hydrolysate combined with urinary kallidinogenase.The treatment efficacy,neurological function,cerebral hemodynamics and the adverse reactions were compared between the two groups.Results The total response rate was 94%in the study group,which was significantly higher compared with 80%in the control group(P<0.05).Before treatment,there were no significant between-group differences in all indicators(P>0.05);after 8 weeks of treatment,the NIH stroke scale(NHISS),Barthel index(BI),the middle cerebral artery mean blood flow velocity(Vmean),cerebral mean blood flow(Qmean),and cerebral vascular resistance(R)in the study group were significantly greater compared with the control group at any give time point(P<0.05).Conclusion Treatment with cerebrotein hydrolysate combined with urinary kallidinogenase for TIA may lead to remarkable therapeutic efficacy and significant improvements in neurological functions and cerebral hemodynamics,and therefore warrants widespread use in clinical settings.