卒中后抑郁与营养代谢相关性及其机制研究进展

Research progress of the relationship between post-stroke depression and nutrition metabolism and the underlying mechanism

卒中后抑郁(PSD)是卒中后最常见的神经精神并发症,卒中幸存者中PSD的总体发病率约33%,PSD的发生对躯体功能、认知功能、心理状况及社会功能均有严重的不良影响,给患者个人、家庭及社会都造成沉重的负担。因此对PSD的早发现、早治疗具有十分重要的临床意义。营养代谢与抑郁和脑卒中均有联系,研究发现其与PSD也密切相关,但在PSD发生发展中的作用机制尚不清楚。本文主要对近年来不同营养代谢与PSD相关性及致病机制研究进展作一综述。

Post-stroke depression(PSD)is the most common neuropsychiatric complication after stroke.The overall incidence of PSD in stroke survivors is approximately 33%.PSD has many serious effects on physical functions,cognitive functions,psychological status and social functions,and it also causes heavily burden patients,families and the society.Therefore,the early recognition and treatment of PSD is of great clinical significance.Nutrition metabolism is closely related to depression and stroke,and has been found to be closely related to PSD.However,the mechanism of nutrition metabolism in the development of PSD is not clear.In this article,we reviewed the scientific progress of the relationship between different nutritional metabolism disorders and PSD in recent years.