钴催化C—H键烯基化反应构建吲哚骨架荧光化合物

Cobalt-Catalyzed Alkenylation of C-H Bond toConstruct Fluorescent Compound Based on Indole Skeleton

以廉价低毒的Cp*Co(Ⅲ)I 2(CO)作为催化剂,N嘧啶基-6-甲酸甲酯基吲哚、苯乙炔作为原料,通过钴催化C-H键烯基化反应在室温条件下,以91%的收率制备了一例吲哚骨架的小分子荧光化合物.对其性质进行了初步探究.发现该化合物具有良好的发光性能,并拥有大Stokes位移.该化合物通过C—H键官能化反应制备,简化了反应路线,提高了反应的原子经济性以及步骤经济性,具有作为荧光染料的应用前景.

By using Cp*Co(Ⅲ)I 2(CO)as the catalyst with methyl 1-(pyrimidin-2-yl)-1H-indole-6-carboxylate and phenylacetylene as the raw materials,an indole-skeleton fluorescent molecule with 91%yield was efficiently synthesized by Co-catalyzed C-H alkenylation at room temperature.The primary properties of the fluorescent molecule were investigated,and the compound showed good fluorescence properties with large Stokes shift.The preparation by C-H functionalization shortened reaction routes and improved atom-economy as well as step-economy,which empowered it to be utilized as fluorescent dyes.