miR-451a在鼻咽癌中的表达与病理特征及预后的相关性

The correlation between the expression of miR-451a in nasopharyngeal carcinoma and its pathological characteristics and prognosis

目的探讨miR-451a在鼻咽癌中的表达与病理特征及预后的相关性。方法选取本院2006年3月~2012年7月经病理活检证实为鼻咽癌的患者95例作为实验对象,采用实时荧光定量RT-PCR法检测鼻咽癌组织、癌旁正常组织中miR-451a的表达水平,对95例患者进行预后随访,并分析miR-451a表达强度与鼻咽癌组织浸润程度、远处转移以及5年生存率的关系。结果鼻咽癌组织的miR-451a表达水平较癌旁正常组织显著增加(P<0.05)。鼻咽癌组织中miR-451a的表达水平随癌组织浸润程度的加深而显著升高(P<0.05)。有远处转移者的miR-451a表达水平显著高于无转移者(P<0.05)。miR-451a高表达的鼻咽癌患者其5年生存率明显低于miR-451a低表达者(P<0.05)。结论miR-451a的异常表达不仅参与鼻咽癌的发生,也有可能促进癌细胞浸润转移,其对于预测患者的生存预后具有一定的参考价值。

Objective To investigate the relationship between the expression of miR-451a in nasopharyngeal carcinoma and its pathological characteristics and prognosis.Methods 95 patients with nasopharyngeal carcinoma confirmed by pathological biopsy from March 2006 to July 2012 were selected as experimental subjects.The expression of miR 451A in nasopharyngeal carcinoma tissues and adjacent normal tissues was detected by real-time fluorescent quantitative RT PCR.The prognosis of the above 95 patients were followed up in detail.The relationship between the expression of miR 451A and the degree of invasion,distant metastasis and 5-year survival rate of nasopharyngeal carcinoma was observed and analyzed.Results The expression level of mir-451a in nasopharyngeal carcinoma tissues was significantly increased compared with normal tissues adjacent to carcinoma(P<0.05).The expression level of mir-451a in nasopharyngeal carcinoma tissues increased significantly with the deepening of the infiltration degree of the carcinoma tissues(P<0.05).The expression level of mir-451a in patients with distant metastasis was significantly higher than those without metastasis(P<0.05).The 5-year survival rate of nasopharyngeal carcinoma patients with high expression of mir-451a was significantly lower than that of those with low expression of mir-451a(P<0.05).Conclusion The abnormal expression of mir-451a is not only involved in the occurrence of nasopharyngeal carcinoma,but also may promote the infiltration and metastasis of cancer cells,which has certain reference value for predicting the survival and prognosis of patients.