胶原酶对小面积深度烧伤创面清创效果分析

Clinical Debridement Effects Analysis of Collagenase in Small Area Deep Burn wounds

为考察胶原酶（ｃｏｌｌａｇｅｎａｓｅ）对小面积深度烧伤创面清创作用的临床疗效和药物不良反应，采用随机、单盲对照、前瞻性临床试验，入选深Ⅱ－Ⅲ度烧伤患者６２例，其中治疗组３３例，对照组２９例。以创面完全清创时间、创面组织坏死率和创面面积缩小百分率为观察指标，分析了胶原酶对小面积深度烧伤创面的清创效果。结果表明，治疗组和对照组两周内创面组织坏死率＜２５％的例数分别为３２（９６．９％）和８例（２７．５９％）；创面完全清创率分别为９０．９１％和６．７０％；创面面积分别缩小４７．４３％和２０．２１％，均具有明显差异（Ｐ＜０．０５－０．０１），同时也表明，胶原酶对创面肉芽的形成和上皮化具有明显的促进作用。治疗中两组病人均具有良好的耐受性。

To evaluate the clinical debridement effects of collagenase in small area deep burns and adverse drug reactions. This study was a randomized single-blind control and prospective clinical trial. 62 patients with deep Ⅱ-Ⅲ burns took pod in the study, 33 in the trial group and 29 in the control group. The debridement time, tissue necrosis rate and recovery of wounds were observed to evaluate collagenase efficacy in debridement of burn wounds. The wound tissue necrosis rate of the trial group and the control group <25% in two Weeks were 32(96.9%) and 8(27.59%) respectively, and wound complete debridement rates were 90.91 % and 6.70%. Wound area reduction rates were 47.42% and 20.21 %.There was a significant difference between the two groups (p<0.05-0.01). It suggests that collagenase can promote granulation form and epithelization. The patients in both groups could tolerate the treatment.