重复经颅磁刺激对急进高原失眠官兵血清中GABA的影响

Effects of rTMS on GABA levels in patients with acute high altitude insomnia

目的:探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对急进高原失眠官兵的治疗效果及可能机制。方法:选取29名急进高原失眠官兵为研究对象,给予rTMS连续治疗10 d,15 min/d。采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)量表评估睡眠质量,并测定血清中伽马氨基丁酸(gamma-aminobutyric acid,GABA)水平,分析睡眠质量与血清中GABA水平的相关性。结果:rTMS治疗后官兵PSQI评分较治疗前显著降低(P<0.01),血清中GABA水平较治疗前显著增高(P<0.01);睡眠质量与血清中GABA水平呈负相关。结论:rTMS可能通过提高血清中GABA水平发挥作用,从而改善急进高原官兵失眠症状。

Objective:To evaluate the treatment effect and mechanism of repetitive transcranial magnetic stimulation(rTMS)on patients with acute altitude insomnia.Methods:Twenty-nine officers and soldiers with attitude insomnia were selected as the reaearch objects.The patients were treated with rTMS for 10 consecutive days,15 min/d.Before and after the whole procedure of rTMS,the sleep quality of patients were assessed by Pittsburgh sleep quality index(PSQI),and serum level of gamma-aminobutyric acid(GABA)in patients was measured by ELISA.Pearson correlation analysis was performed to evaluate the correlation between sleep quality and the level of GABA.Results:After rTMS treatment,the PSQI score was significantly lower than that before treatment(P<0.01),the level of serum GABA was significantly higher than that before treatment(P<0.01).Pearson correlation analysis showed that the sleep quality was negatively associated with the GABA level.Conclusion:rTMS may improve the insomnia symptoms of acute altitude,and increasing the level of GABA.