摘要
炎症性肠病(IBD)是一种病因不明的慢性特发性炎症性疾病,目前发病机制尚不明确,治疗药物主要包括5-氨基水杨酸类、激素、生物制剂、免疫抑制剂等,但长期使用激素、免疫抑制剂等药物的患者发生机会性感染的风险增加。EB病毒感染属于IBD机会性感染,近年来,IBD合并EB病毒感染导致难治性IBD、EB病毒相关性淋巴细胞增殖性疾病、淋巴瘤、嗜血细胞综合征等报道逐渐增多。本文介绍了IBD合并EB病毒感染的流行病学、临床特点、内镜及组织学表现和治疗的研究进展。
Inflammatory bowel disease(IBD)is a kind of chronic idiopathic inflammatory diseases,its pathogenesis is not clear.The treatments including 5-aminosalicylic acid,adrenocortical hormone,biological agents,immunosuppressor,etc.However,adrenocortical hormone and immunosuppressor increase the risk of opportunistic infection in patients.Epstein-Barr virus infection is an opportunistic infection of IBD.In recent years,the reports about EBV infection in IBD led to refractory IBD,EBV-related lymphoproliferative diseases,lymphoma,and haemophilic cell syndromewere increasing.The progress of the epidemiology,clinical features,endoscopic and histological detection and treatment of EBV infection in IBD was presented.
作者
周联玉
缪应雷
ZHOU Lian-yu;MIAO Ying-lei(Department of Gastroenterology,the First Affiliated Hospital of Kunming Medical University,Yunnan Province,Kunming650032,China)
出处
《中国当代医药》
2020年第26期24-27,共4页
China Modern Medicine
基金
国家自然科学基金资助项目(81670501)
云南省创新团队计划项目(2017HC005)。
关键词
炎症性肠病
EB病毒
机会性感染
治疗
Inflammatory bowel disease
Epstein-Barr virus
Opportunistic infection
Treatment
