摘要
目的探讨13C-尿素呼气试验定量值与胃窦黏膜病变程度的关系。方法选取2017年1月1日~2018年12月31日上海中医药大学附属龙华医院在1周内完成了13C-尿素呼气试验定量检测和胃窦黏膜组织学检查的103例住院患者的临床资料,对13C-尿素呼气试验定量值和5种胃窦黏膜病理病变评分做相关性分析。结果13C-尿素呼气试验定量值与幽门螺杆菌(Hp)数量、胃窦黏膜慢性炎症病变程度、胃窦活动性成正相关(r=0.257、0.229、0.238,P<0.05),与胃窦萎缩、肠化病变程度不相关(P>0.05)。结论临床上可根据无创的13C-尿素呼气试验定量值预测胃内的Hp数量和胃窦炎的程度,从而指导临床诊治。
Objective To explore the relationship between 13C-urea breath test(UBT)value and severity of gastric antral mucosal lesions.Methods A total of 103 cases inpatients who underwent the 13C-UBT and gastric tissue biopsy within a week in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 1,2017 to December 31,2018 were included in the study.The severity of antral mucosal lesions was graded pathologically,and the correlation between 13C-UBT values and the five different histopathological grades was analyzed.Results The quantitative value of the 13C-UBT was positively correlated with the number of Helicobacter pylori(Hp),the degree of chronic inflammation of the gastric antral mucosa,and the activity of the gastric antrum(r=0.257,0.229,0.238,P<0.05),but was not related to the degree of antral atrophy and intestinal metaplasia(P>0.05).Conclusion Clinically,the quantitative value of the non-invasive 13C-UBT can be used to predict the number of Hp in the stomach and the degree of gastritis to guide clinical diagnosis and treatment.
作者
温红珠
薛嬴俊
何泽慧
苑致维
邵兰君
朱凌宇
林江
WEN Hong-zhu;XUE Ying-jun;HE Ze-hui;YUAN Zhi-wei;SHAO Lan-jun;ZHU Ling-yu;LIN Jiang(Department of Gastroenterology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Laboratory,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国当代医药》
2020年第26期39-41,48,共4页
China Modern Medicine
基金
国家自然科学基金资助项目(81703986)
上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-FWTX-4018]
海派中医流派(丁氏内科)黄文东临床传承研究(ZY3-CCCX-1-1001)。
关键词
13C-尿素呼气试验
幽门螺杆菌
胃窦黏膜
活动性
慢性炎症
13C-urea breath test
Helicobacter pylori
Antral mucosa
Active inflammation
Chronic inflammation