乳腺组织标记定位针在乳腺癌新辅助化疗后保乳手术中的应用

Application of ultra clip dual trigger breast tissue marker in breast conserving surgery after the neoadjuvant treatment

目的:探讨乳腺组织标记定位针(靶钉)对可手术乳腺癌保乳率的影响。方法:回顾性分析自靶钉置入技术开展以来13例可手术乳腺癌病例,化疗期间于癌灶内通过超声引导置入靶钉,对足疗程新辅助化疗后进行保乳切除手术的保乳手术实施情况,分析化疗后的病理完全缓解(pathological complete response,pCR)率及术后局部复发和远处转移情况,对比靶钉置入前后对乳腺癌保乳手术率的影响。结果:13例靶钉置入的乳腺癌患者均足疗程完成了新辅助化疗,其中10例完成了保乳手术,保乳率达76.9%(10/13),较靶钉置入技术开展前2017年的保乳手术率26.31%(226/859)明显提高。术后中位随访4个月(2~19个月,38.5%随访10个月以上)无局部复发和远处转移。结论:靶钉置入有利于提高新辅助化疗后乳腺癌的保乳手术率。

Objective:To investigate the effect of breast tissue markers(target nail)on breast-conserving rate of operable breast cancer.Methods:A retrospective analysis of 13 cases of operable breast cancer since the introduction of target nail placement technology was performed.During chemotherapy,each patient placed a target nail in a breast cancer lesion under ultrasound guidance.Breast-conserving surgery rate,pathological complete response(pCR)rate after neoadjuvant chemotherapy,and the postoperative local recurrence and distant metastasis were analyzed.Breast-conserving surgery rate before and after target nail placement technology was compared.Results:All 13 breast cancer patients with target nail placement completed neoadjuvant chemotherapy,and 10 of them completed breast-conserving surgery with a breast-conservation rate of 76.9%(10/13).The rate of breast-conserving surgery in 2017 was 26.31%(226/859).The median follow-up was 4 months(2–19 months,38.5%more than 10 months)without local recurrence and distant metastasis.Conclusion:Target nail placement is beneficial to improve breastconserving surgery rate of breast cancer after neoadjuvant chemotherapy.