摘要
目的探讨影响子宫肉瘤患者预后的相关因素。方法回顾性分析随访资料完整的子宫肉瘤患者83例,单因素及多因素回归分析讨论临床病理特征与患者5年总生存率的关系。结果所有患者中位数随访时间为63(13~120)个月。83例患者1、3和5年总生存率分别为91.6%、65.1%和44.6%,5年复发率为51.8%。18例行二次分期手术的患者中10例复发,5年总生存率为45.5%。各病理类型分组中,行二次手术的患者与所有患者的5年总生存率比较,差异均无统计学意义(均P>0.05)。单因素分析显示,患者5年总生存率在肿瘤直径、肿瘤标志物糖类抗原125(carbohydrate antigen 125,CA125)水平、脉管内癌栓情况、淋巴结转移情况、国际妇产科协会(Federation International of Gynecology and Obstetrics,FIGO)分期和病理类型方面比较,差异均具有统计学意义(均P<0.05)。Cox回归分析显示,肿瘤大小(RR=1.89,95%CI:1.08~3.01,P=0.041)、FIGO分期(RR=2.21,95%CI:1.51~3.23,P<0.01)和脉管内癌栓(RR=2.42,95%CI:1.53~3.48,P=0.001)为子宫肉瘤预后的独立危险因素。结论肿瘤大小、FIGO分期和脉管内癌栓情况为子宫肉瘤预后的独立危险因素。
Objective To investigate the prognostic factors of patients with uterine sarcoma.Methods The data of 83 patients with uterine sarcoma and completed follow-up were retrospectively analyzed.Univariate and multivariate regression analysis were used to investigate the relationship between clinical pathological features and five-year overall survival.Results The median follow-up time for all patients was 63(range 13-120)months.1-,3-and 5-year overall survival rates of all patients were 91.6%、65.1%and 44.6%,and the 5-year recurrence rate was 51.8%.Among the 18 patients undergoing second stage surgery,10 had recurrence and the 5-year overall survival rate was 45.5%.Grouped in various pathological types,the 5-year overall survival rates of all patients and those with second stage surgery were not significantly different(all P>0.05).Univariate analysis showed that tumor size,carbohydrate antigen 125(CA125)level,vascular invasion,lymph node metastasis,International Federation of Gynecology and Obstetrics(FIGO)stage and pathological type were the main factors affecting the prognosis(all P<0.05).Cox regression analysis showed that tumor size(RR=1.89,95%CI:1.08-3.01,P=0.041),FIGO stage(RR=2.21,95%CI:1.51-3.23,P<0.01)and vascular invasion(RR=2.42,95%CI:1.53-3.48,P=0.001)were independent risk factors for prognosis of uterine sarcoma.Conclusions Tumor size,FIGO stage and vascular invasion are independent risk factors of the prognosis of uterine sarcoma.
作者
程广艳
王明宇
曲芃芃
Cheng Guangyan;Wang Mingyu;Qu Pengpeng(Department of Gynecological Oncology,Tianjin Central Hospital of Gynecology and Obstetrics,Tianjin 300100,China)
出处
《实用肿瘤杂志》
CAS
2020年第5期454-458,共5页
Journal of Practical Oncology
关键词
子宫肉瘤
预后分析
回顾性研究
uterine sarcoma
prognosis
retrospective study