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环状RNA作为微小RNA海绵在结直肠癌中的作用及其临床价值 被引量:2

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摘要 环状RNA(circular RNA,circRNA)是一种特殊的非编码RNA(non-coding RNA,ncRNA)分子,具有结构稳定、数量众多和高度保守等特性,能够充当微小RNA(microRNA,miRNA)分子海绵、调节基因的转录及剪接以及参与蛋白质的翻译等。近来研究表明,circRNA作为miRNA海绵,通过调节miRNA的活性,在肿瘤的发病机制中发挥一定作用。结直肠癌(colorectal cancer,CRC)是最常见的恶性肿瘤之一。circRNA作为miRNA分子海绵与CRC细胞增殖、迁移、侵袭和凋亡等病理过程关系密切,对CRC发生、发展、早期诊断以及预后评估具有重要作用。
出处 《实用肿瘤杂志》 CAS 2020年第5期473-478,共6页 Journal of Practical Oncology
基金 宁波市自然科学基金(2016A610121)。
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  • 1Qi Guo,Yongchun Song,Hao Zhang,Xuandi Wu,Peng Xia,Chengxue Dang.Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients[J].Medical Oncology.2013(4)
  • 2T.‐H. Chen,S.‐W. Chang,C.‐C. Huang,K.‐L. Wang,K.‐T. Yeh,C.‐N. Liu,H. Lee,C.‐C. Lin,Y.‐W. Cheng.The prognostic significance of APC gene mutation and miR‐21 expression in advanced‐stage colorectal cancer[J].Colorectal Dis.2013(11)
  • 3Lars Henrik Jensen,Anders Aamann Rasmussen,Lene Byriel,Hidekazu Kuramochi,Dorthe Gylling Crüger,Jan Lindebjerg,Peter V. Danenberg,Anders Jakobsen,Kathleen Danenberg.Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study[J].Cellular Oncology.2013(5)
  • 4Jens Neumann,Laura Wehweck,Susanne Maatz,Jutta Engel,Thomas Kirchner,Andreas Jung.Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis[J].Virchows Archiv.2013(4)
  • 5Qi Xu,An Tao Xu,Ming Ming Zhu,Jin Lu Tong,Xi Tao Xu,Zhi Hua Ran.Predictive and prognostic roles of BRAF mutation in patients with metastatic colorectal cancer treated with anti‐epidermal growth factor receptor monoclonal antibodies: A meta‐analysis[J].Journal of Digestive Diseases.2013(8)
  • 6TaeJeong Oh,Nayoung Kim,Youngho Moon,Myung Soon Kim,Benjamin D. Hoehn,Chan Hee Park,Tae Soo Kim,Nam Kyu Kim,Hyun Cheol Chung,Sungwhan An.Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2 , for Blood-Based Detection of Colorectal Cancer[J].The Journal of Molecular Diagnostics.2013(4)
  • 7Jung Wook Huh,Hyeong Rok Kim,Young Jin Kim.Prognostic Role of p53 Messenger Ribonucleic Acid Expression in Patients after Curative Resection for Stage I to III Colorectal Cancer: Association with Colon Cancer Stem Cell Markers[J].Journal of the American College of Surgeons.2013(6)
  • 8Yu Zhang,Xinying Wang,Binghong Xu,Baocai Wang,Zhongqiu Wang,Yan Liang,Jieqiong Zhou,Jingjing Hu,Bo Jiang.Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesisin colorectal cancer[J].Oncology Reports.2013(4)
  • 9N. Devaud,S. Gallinger.Chemotherapy of MMR-deficient colorectal cancer[J].Familial Cancer.2013(2)
  • 10Allison M. Cushman-Vokoun,Daniel G. Stover,Zhiguo Zhao,Elizabeth A. Koehler,Jordan D. Berlin,Cindy L. Vnencak-Jones.Clinical Utility of KRAS and BRAF Mutations in a Cohort of Patients With Colorectal Neoplasms Submitted for Microsatellite Instability Testing[J].Clinical Colorectal Cancer.2013

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