恶性高热的临床及基础研究进展

Advancements of Clinical and Basic Research in Malignant Hyperthermia

恶性高热(malignant hyperthermia,MH)是一种较为罕见的遗传性疾病,主要表现为接触挥发性麻醉剂或去极化肌松剂时出现体温急剧升高,骨骼肌剧烈收缩进而引发一系列病理变化。患者发病前难以诊断,病情发展十分迅速,若得不到有效救治,则极易出现生命危险。随着各类麻醉药物在口腔临床中的广泛应用,口腔医生遇到MH的机率逐渐增加,且其治疗手段有一定的特殊性,若误诊误治可能导致患者死亡。因此,本文对MH的临床及基础研究进展行一综述。

Malignant hyperthermia(MH)is a rare genetic disease which characterized by a sharp rise in body temperature and a series of pathological changes caused by severe contraction of skeletal muscle when exposed to volatile anesthetics or depolarizing muscle relaxants.The patient is difficult to diagnose before the onset of the disease.The development MH is very rapid,and if not effectively treated,it is very easy to appear life-threatening.With the wide application of various anesthetics in the clinic,the probability to encounter MH is increasing gradually.However,the treatment methods are certain particular.Misdiagnosis and mistreatment may lead to the death of patients.Therefore,this paper reviews the clinical and basic research progress of MH.