共挤出流体法制备功能化胶囊膜的研究进展

Recent progress in preparation of functional capsule membranes based on co-extrusion minifluidic technique

胶囊膜作为一种封装系统,由于具有独特的内部空腔结构,能够对活性物质进行封装保护而广泛应用于物质封装和药物控制释放等领域。其中,以海藻酸钙(Ca-Alg)作为壁材构建的胶囊膜具有优异的生物相容性和可降解性。共挤出流体法由于具有制备过程简单、条件温和、胶囊粒径均一以及结构和功能可控等特点,为Ca-Alg胶囊膜的制备提供了一种有效的新手段。主要综述了近年来基于共挤出流体法构建Ca-Alg胶囊膜及其功能化的研究进展,重点介绍了基于共挤出流体法构建单腔室和多腔室胶囊膜、胶囊膜的跨膜传质影响因素,以及利用胶囊膜包埋细胞构建研究肿瘤变化机制的模型和利用功能性材料实现胶囊膜的功能化改性及其应用等方面的研究进展。

As a kind of encapsulation system,the capsule membrane has a unique internal cavity structure,which can encapsulate and protect active substances and is widely used in the fields of substance encapsulation and controlled release of drugs.Capsule membranes fabricated with calcium alginate(Ca-Alg)as shells process notable advantages such as good biocompatibility and degradability.Compared with other fabrication methods,co-extrusion minifluidic technique has the advantages of facile fabrication process and mild conditions for fabrication of Ca-Alg capsule membranes with uniform size and regulated structures.This paper reviews recent progress in fabrication and functionalization of Ca-Alg capsule membranes by co-extrusion minifluidic technique.Fabrication of Ca-Alg capsule membranes with single and multi-compartment,factors affecting mass transfer of Ca-Alg capsule membranes,encapsulation of cells for producing multicellular spheroids and investigating the mechanics of tumor progression in vitro with three-dimensional environments,and functionalization of Ca-Alg capsule membranes by addition of functional materials with thermo and pH-responsive switching functions are highlighted.This review provides guidance for the further design and fabrication of novel capsule membranes as well as their applications in enzyme catalytic reactions,immobilizations of cells and foods,and controlled release of chemicals.