灵芝发酵菌丝提取物组成成分与急性毒性分析

Composition and acute toxicity of Ganoderma lingzhi mycelium extract

灵芝(Ganoderma lingzhi)是我国传统的名贵药食用真菌之一,具有很高的药用价值。笔者对灵芝发酵菌丝提取物(Ganoderma lingzhi mycelium extract,GLME)的主要化学成分及急性毒性进行了分析,结果表明:GLME的主要成分包括蛋白质(14.35%)、水解氨基酸(6.60%)、粗多糖(5.74%)、多种矿物质、不饱和脂肪酸及核苷类等。14 d急性毒性实验显示:小鼠灌胃GLME在实验期内无死亡率,其体质量、器官质量、谷草转氨酶(aspartate aminotransferase,AST)和谷丙转氨酶(alanine aminotransferase,ALT)活性与对照组相比无统计学差异。因此GLME具有进一步开发的潜在应用价值。

Ganoderma lingzhi is one of the traditional and valuable medicine and edible fungi,with high pharmacological activity.In this study,the main chemical components and acute toxicity of Ganoderma lingzhi mycelium extract(GLME)were analyzed.The main components of GLME were protein(14.35%),hydrolyzed amino acid(6.60%),crude polysaccharide(5.74%),various minerals,unsaturated fatty acids and nucleosides.A 14-day acute toxicity experiments showed that mice given GLME by gavage administration had no mortality during the experimental period,and there was no significant difference in their body weight,organ weight,the activity of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)compared with the control group.Therefore,GLME has potential application value for further development.