木丹颗粒联合甘精胰岛素治疗痛性糖尿病周围神经病变的效果观察

Effects of Mudan granule combined with insulin glargine on painful diabetic peripheral neuropathy

目的:探讨木丹颗粒联合甘精胰岛素治疗痛性糖尿病周围神经病变的临床效果。方法:抽取2017年3月至2018年9月在日照市人民医院就诊的痛性糖尿病周围神经病变患者70例,根据随机数字表法分为对照组和观察组,每组35例。对照组采用甘精胰岛素睡前皮下注射;观察组在对照组治疗基础上采用木丹颗粒口服治疗。分析两组治疗4周时的临床疗效,比较两组治疗前、后丙二醛(MDA)、超氧化物歧化酶(SOD)水平、腓总神经传导速度、视觉模拟评分法(VAS)评分及不良反应发生情况。结果:观察组临床治疗总有效率(85.71%,30/35)高于对照组(62.86%,22/35),P<0.05。治疗后,两组MDA水平均低于治疗前,SOD水平升高,且观察组治疗后MDA水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组运动神经传导速度及感觉神经传导速度均高于治疗前,且观察组治疗后运动神经传导速度及感觉神经传导速度高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未见明显不良反应。结论:木丹颗粒联合甘精胰岛素治疗痛性糖尿病周围神经病变,可有效降低患者氧化应激反应,提高神经传导速度,改善疼痛程度,提高临床治疗效果。

Objective To investigate the clinical effects of Mudan granule combined with insulin glargine in the treatment of patients with painful diabetic peripheral neuropathy.Methods A total of seventy patients with painful diabetic peripheral neuropathy who were admitted to Rizhao People’s Hospital from March 2017 to September 2018 were selected and divided into control group and observation group according to the random number table method.The control group was treated with insulin glargine,injected subcutaneously before sleep;the observation group was treated with Mudan granules on the basis of treatment of the control group.The clinical efficacy of the two groups was analyzed after 4 weeks of treatment.The levels of malondialdehyde(MDA),superoxide dismutase(SOD),peroneal nerve conduction velocity,visual analogue scale(VAS)score and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group(85.71%,30/35)was significantly higher than that of the control group(62.86%,22/35),P<0.05.After treatment,MDA levels in both groups decreased,and SOD level increased,in comparison to preoperative levels(P<0.05).After treatment,MDA level was lower,and SOD level was higher in the observation group,in comparison to the control group(P<0.05).After treatment,motor nerve conduction velocity and sensory nerve conduction velocity in both groups were higher,in comparison to preoperative values(P<0.05);and they were higher in the observation group than that in the control group,with statistically significant differences(P<0.05).After treatment,VAS scores of the two groups were lower than those before treatment,and VAS scores of the observation group were lower than those of the control group(P<0.05).No significant adverse reactions occurred during the treatment in either group.Conclusions Mudan granule combined with insulin glargine can effectively reduce oxidative stress response,improve nerve conduction velocity,alleviate pain degree,improve clinical therapeutic effect in patients with painful diabetic peripheral neuropathy.