我国真核细胞微核及染色体畸变在不同领域的检测进展

Detection progress of micronuclei and chromosomal aberration of eukaryotic cells in China

真核生物受到特定外源性刺激因子的影响,细胞会呈现出微核、染色体断裂、双着丝粒、环状染色体等畸变形态。国外对该变异的研究和应用日趋成熟,我国在该领域亦探索出符合我国国情的检测方法,尤其是在医疗放射人员职业疾病防控领域力求深入。本文对我国真核细胞微核及染色体畸变检测技术的原理、方法及应用加以综述。

When eukaryotes are affected by specific exogenous stimulus,the cells will present aberrant forms such as micronuclei,chromosome breakage,dicentric centromeres,and ring chromosomes.The research and application of the mutation in foreign countries are becoming more and more mature.China has also explored a suitable detection technology in this field according to the national conditions,especially in the field of occupational disease prevention and control in medical radiation workers.This paper mainly reviews the principle,method and application of the detection technology of micronuclei and chromosomal aberration in eukaryotic cells in China.