血清SAA、CK、ET水平在小儿急性感染性腹泻病情评估中的价值

Serum SAA,CK and ET Levels of Children with Acute Infectious Diarrhea

目的探讨血清淀粉样蛋白A(serum amyloid A,SAA)、血清肌酸激酶(creatine kinase,CK)及内皮素(endothelin,ET)水平在评估小儿急性感染性腹泻病情严重程度中的价值。方法将2017年2月~2018年11月至本院儿科就诊的173例急性感染性腹泻患儿设定为观察组。分析其血清SAA、CK及ET水平,并比较观察组中不同病情严重程度患儿以上指标水平差异。结果治疗前,不同病情严重程度患儿血清SAA、CK及ET水平有统计学差异,重型组>中型组>轻型组(P<0.05);血清SAA、CK、ET水平均与小儿急性感染性腹泻严重程度呈正相关(r=5.320,P=0.007;r=4.419,P=0.034;r=5.852,P=0.016);治疗后,患儿以上指标水平较治疗前下降(P<0.05)。结论血清SAA、CK、ET水平在评估小儿急性感染性腹泻病情严重程度中具有重要意义,可作为协助评判小儿急性感染性腹泻严重程度的生物学指标。

Objective To explore the value of serum amyloid A(SAA),creatine kinase(CK)and endothelin(ET)levels for assessing the severity of acute infective diarrhea in children.Methods From February 2017 to November 2018,173 children with acute infectious diarrhea were set up as observation group.The serum SAA,CK and ET levels were compared in observation group.Results Before treatment,SAA,CK,ET levels in children with different illness severity were significantly different,severe group>medium group>light group(P<0.05).SAA,CK and ET levels were positively associated with the severity of acute infectious diarrhea in children(r=5.320,P=0.007;r=4.419,P=0.034;r=5.852,P=0.016).After treatment,the levels of markers were lower than those before treatment in observation group(P<0.05).Conclusion Serum SAA,CK and ET levels are of great significance in evaluation of the severity of acute infectious diarrhea in children,and can be used as markers to assist in assessing the severity of acute infectious diarrhea in children.