腹腔镜术联合醋酸甲地孕酮应用于早期子宫内膜癌治疗中疗效分析

Laparoscopy combined with medroxyprogesterone acetate in the treatment of early endometrial cancer

目的:探讨腹腔镜术联合醋酸甲地孕酮治疗早期子宫内膜癌的疗效。方法:将102例患者随机分为研究组和对照组。对照组51例,予以腹腔镜术及术后化疗;研究组51例,予以腹腔镜术及醋酸甲地孕酮。比较组间差异。结果:研究组总有效率为96.08%,优于对照组的80.39%(P<0.05)。术后2年,两组CA125水平均较术前有显著下降(P<0.01),其中,研究组下降幅度明显高于对照组(P<0.01)。随访2年,研究组复发率为5.88%,低于对照组的23.53%,χ^2=5.002,P<0.05,差异具有统计学意义。结论:腹腔镜术联合醋酸甲地孕酮有利于提升疗效,减少复发。

Objective:To explore the effect of laparoscopy combined with medroxyprogesterone acetate in the treatment of early endometrial cancer.Methods:102 patients were randomly divided into study group and control group.51 cases in the control group were treated with laparoscopy and chemotherapy;51 cases in the study group were treated with laparoscopy and medroxyprogesterone acetate.The differences between groups were compared.Results:The total effective rate of the study group was 96.08%,which was superior to 80.39%of the control group(P<0.05).Two years after operation,the CA125 levels in both groups were significantly lower than that before operation(P<0.01),and the decrease in the study group was significantly higher than that in the control group(P<0.01).The recurrence rate of the study group was 5.88%,lower than that of the control group(23.53%),χ^2=5.002,P<0.05,the difference was statistically significant.Conclusion:Laparoscopy combined with medroxyprogesterone acetate is beneficial to the improvement of curative effect and the reduction of recurrence.