促红细胞生成素对神经退行性疾病的作用

Recent implications of erythropoietin in neurodegenerative diseases

促红细胞生成素(Erythropoietin,EPO)主要是人体肾脏分泌的一种具有生物活性的酸性糖蛋白,在正常生理状态下能够促进红系祖细胞增殖、分化与成熟,在红细胞形成、骨髓造血方面发挥重要作用,在医学上主要用于慢性贫血治疗。近几年来,更多的实验证据显示,促红细胞生成素对神经系统具有明显保护作用,它主要通过不同信号转导途径对神经系统进行调节,其中EPO/EPOR(Erythropoietin receptor,EPOR,促红细胞生成素受体)在神经退行性疾病领域中已经被广泛研究,EPO与EPOR相互作用可激活下游不同靶分子,最终达到调节神经系统的目的。EPO在多种神经退行性疾病中都具有潜在的治疗作用,例如帕金森病、阿尔茨海默氏病、脊髓损伤以及脑缺血。主要对目前报道的EPO在神经退行性疾病方面的作用机制进行综述。

Erythropoietin(EPO)is a acid glycoprotein with biological activity mainly secreted by the human kidney,which can promote the proliferation,differentiation and maturation of erythroid progenitor cells under normal physiological conditions.It plays an important role in the formation of red blood cells and bone marrow hematopoiesis,and is mainly used in the treatment of chronic anemia in medicine.In recent years,more and more studies have shown that EPO has neuroprotective effects and can regulate the nervous system through different signal transduction pathways.Among them,EPO/EPOR(Erythropoietin receptor,EPOR)has been widely studied in the neurodegenerative diseases field.The interaction between EPO and EPOR can activate different downstream target molecules,and finally achieve the purpose of regulating the nervous system.EPO has potential therapeutic effects in a variety of neurodegenerative diseases,such as Parkinson′s disease,Alzheimer′s disease,Spinal cord injury and Brain ischemia.This review focused on the recent implications of erythropoietin in neurodegenerative diseases.