乳酸脱氢酶、肿瘤标志物与肺泡蛋白沉着症患者病情严重程度的相关性分析

Correlation between lactate dehydrogenase,tumor markers and the severity of pulmonary alveolar proteinosis

目的探讨乳酸脱氢酶(LDH)、肿瘤标志物与肺泡蛋白沉着症(PAP)患者病情严重程度的关系。方法收集57例PAP患者的临床资料,分析血清LDH水平与肺功能指标、血清LDH水平与肿瘤标志物、肿瘤标志物与疾病严重程度评分(DSS)的相关性。结果PAP患者血清LDH水平与PaO2(r=-0.42,P=0.001)、一氧化碳弥散(r=-0.73,P<0.001)、FEV1(r=-0.40,P=0.004)呈负相关。PAP患者的神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、癌抗原153(CA153)和细胞角蛋白19片段CYFRA21-1均高于正常上限(P均<0.05)。PAP患者的NSE(rs=0.39,P=0.003)、CEA(rs=0.55,P<0.001)、CA153(rs=0.48,P<0.001)、CYFRA21-1(rs=0.44,P=0.001)水平与DSS均呈正相关。结论PAP患者血清中LDH与肺功能指标呈负相关,肿瘤标志物NSE、CEA、CA153和CYFRA21-1升高并与病情严重程度呈正相关,LDH和肿瘤标志物水平可能反映了PAP患者的病情严重程度。

Objective To investigate the correlation between lactate dehydrogenase(LDH),tumor markers and the severity of pulmonary alveolar proteinosis(PAP).Methods Clinical data of 57 PAP patients were retrospectively analyzed.The correlation between serum LDH level and pulmonary function,serum LDH level and tumor markers,and tumor markers and disease severity score(DSS)were analyzed.Results In PAP patients,the serum level of LDH was negatively correlated with PaO2(r=-0.42,P=0.001),carbon monoxide diffusing capacity(DLCO)(r=-0.73,P<0.001)and forced expiratory volume in one second(FEV1)(r=-0.40,P=0.004),respectively.In PAP patients,the neuron-specific enolase(NSE),carcinoembryonic antigen(CEA),cancer antigen 153(CA153)and CYFRA21-1 were significantly higher than the upper limits(all P<0.05).The NSE(rs=0.39,P=0.001),CEA(rs=0.55,P<0.001),CA153(rs=0.48,P<0.001)and CYFRA21-1(rs=0.44,P=0.001)were positively correlated with DSS.Conclusions The serum level of LDH is negatively correlated with lung function indexes in PAP patients.The serum levels tumor makers such as of NSE,CEA,CA153 and CYFRA21-1 are significantly elevated and positively correlated with the severity of the disease in PAP patients.LDH and tumor makers can reflect the severity of PAP.