MEIS1在子宫内膜样腺癌中的表达及其临床意义

Expression and significance of MEIS1 in the endometrial adenocarcinoma

目的探讨骨髓嗜病毒整合位点1(MEIS1)在子宫内膜样腺癌中的表达及其临床意义。方法选取45例子宫内膜样腺癌患者的病变组织(内膜癌组),以及12例非内膜病变患者的正常子宫内膜组织(对照组),采用免疫组织化学染色检测2组组织中MEIS1蛋白的阳性率,分析内膜癌组MEIS1蛋白与临床病理特征、雌激素受体(ER)和孕激素受体(PR)间的关系。结果子宫内膜样腺癌组织中,MEIS1蛋白主要表达于腺上皮细胞胞核中。内膜癌组的MEIS1蛋白阳性率高于对照组(P<0.05)。子宫内膜样腺癌组织中,MEIS1的表达与腺癌细胞分化级别、分期、肌层浸润深度、淋巴结转移、脏器转移等均无关(P均>0.05),与ER、PR的表达有关(P均<0.05)。结论MEIS1在子宫内膜样腺癌中呈高表达,并与ER、PR的表达相关,可能参与了子宫内膜样腺癌的发生机制。

Objective To investigate the expression and clinical significance of myeloid ecotropic viral integration site 1(MEIS1)in the endometrial adenocarcinoma.Methods The diseased endometrial tissues were collected from 45 patients with endometrial adenocarcinoma(endometrial adenocarcinoma group)and normal endometrial tissues were obtained from 12 patients with non-endometrial lesions(control group).The positive rate of MEIS1 in two groups was detected by immunohistochemical staining.The correlation between MEIS1 protein,clinicopathological features,estrogen receptor(ER)and progesterone receptor(PR)in the endometrial adenocarcinoma group was analyzed.Results MEIS1 protein was mainly expressed in the nuclei of glandular epithelial cells in the endometrial adenocarcinoma tissues.The positive expression rate of MEIS1 protein in the endometrial adenocarcinoma group was significantly higher than that in the control group(P<0.05).In the endometrial adenocarcinoma tissues,MEIS1 expression was not correlated with the differentiation grade of adenocarcinoma cells,stages,myometrial infiltration,lymph node metastasis or organic metastasis(all P>0.05),whereas it was significantly associated with the expression of ER and PR(both P<0.05).Conclusions MEIS1 is highly expressed in endometrial adenocarcinoma,which is associated with ER and PR expression.In addition,MEIS1 might be involved with the pathogenesis of endometrial adenocarcinoma.