左旋氧氟沙星注射剂与环丙沙星注射剂随机对照治疗细菌性感染的临床研究

A Randomized Comparative Clinical Study of Levofloxacin iv. vs Ciprofloxacin iv. in the Treatment of Bacterial Infections

评价左旋氧氟沙星的临床有效性与安全性。采用前瞻性随机对照试验方法。试验药为左旋氧氟沙星，每次200－300mg，静脉滴注，每日2次。对照药为环丙沙星，每次200－400mg，静脉滴注，每日2次。疗程均为7－14d。结果为试验组38例与对照组35例的两组治愈率分别是76．3％与68．6％。有效率分别是97．4％与97．1％，细菌清除率分别是88．6％与89．7％。药物不良反应发生率分别是79％（3／38）与5．6％（2／36），统计学均无显著性差异。结论为左旋氧氟沙皇对于临床常见的呼吸道、泌尿道、肠道细菌感染是一种安全、有效的药物。

To evaluate the clinical efficacy and safety of levofloxacin. A prospectiverandomized-controlled clinical trial was carried out. Levofloxacin as a trial drug wasadministered in 200~300 mg doses, twice a day by iv. infusion. Ciprofloxacin as a controldrug was 200~400mg, twice a day by iv infusion. The treatment lasted for 7~14 days.Resultst 38 patients were treated with levofloxacin and 35 patients were treated withciprofloxacin. The clinical cure rates of the two groups were 76.3% and 68.6% respectively.The clinical effcacy rates were 97.4% and 97. 1 % respectively. The bacterial clearancerates were 88.6% and 89.7% respectiveIy. The adverse drug reaction rates were 7.9%(3/38)and 5.6%(2/36) respectively. There were no statistical differences. Levofloxalin is a safeand effective drug in the treatment of infections of the respiratory, urinary and alimentarytracts.