黄芩汤联合化疗治疗结肠癌临床研究

Clinical Study on Huangqin Tang Combined with Chemotherapy for Colon Cancer

目的:观察黄芩汤联合化疗治疗结肠癌的临床疗效。方法:选取84例结肠癌患者,按随机数字表法分为观察组和对照组各42例。对照组采用CMF化疗方案,观察组在对照组基础上口服黄芩汤。比较2组治疗前后T淋巴细胞亚群、炎症因子、免疫球蛋白水平。结果:治疗前,2组CD8^+、CD3^+、CD4^+、CD4^+/CD8^+比较,差异无统计学意义(P>0.05)。治疗后,2组CD8^+较治疗前降低,CD3^+、CD4^+、CD4^+/CD8^+较治疗前升高;且观察组CD8^+低于对照组,CD3^+、CD4^+、CD4^+/CD8^+高于对照组;差异均有统计学意义(P<0.05)。治疗前,2组干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05)。治疗后,对照组IFN-γ、IL-2水平较治疗前升高,IL-4水平较治疗前降低;观察组IFN-γ、IL-2水平高于治疗前和对照组,IL-4、IL-6水平低于治疗前和对照组;差异均有统计学意义(P<0.05)。治疗前,2组免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A (IgA)水平比较,差异无统计学意义(P>0.05)。治疗后,对照组IgG、IgM水平较治疗前升高,观察组IgG、IgM、IgA水平高于治疗前和对照组,差异均有统计学意义(P<0.05)。结论:黄芩汤联合化疗治疗结肠癌的临床效果显著,能有效改善患者T淋巴细胞及免疫功能,缓解炎症反应,提高免疫球蛋白水平。

Objective: To observe the clinical effect of Huangqin tang combined with chemotherapy for colon cancer.Methods:A total of 84 cases of patients with colon cancer were selected and divided into the observation group and the control group according to the random number table method,42 cases in each group. The control group was treated with CMF regimen, and the observation group was additionally given the oral administration of Huangqin tang based on the treatment of the control group. Before and after treatment,the levels of T lymphocyte subsets,inflammatory factors and immunoglobulin in the two groups were compared. Results: Before treatment, there was no significant difference being found in the comparison of the levels of CD8^+, CD3^+, CD4^+, and CD4^+/CD8^+between the two groups(P>0.05). After treatment,CD8^+levels in the two groups were decreased when compared with those before treatment,and the levels of CD3^+,CD4^+and CD4^+/CD8^+were increased;the level of CD8^+in the observation group was lower than that in the control group,and the levels of CD3^+,CD4^+and CD4^+/CD8^+were higher;differences being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of interferon-γ(IFN-γ),interleukin-2(ILl-2),interleukin-4(IL-4) and interleukin-6(IL-6) between the two groups(P>0.05). After treatment,the levels of IFN-γ and IL-2 in the control group were increased when compared with those before treatment and IL-4 level was decreased;the levels of IFN-γ and IL-2 in the observation group were higher than those before treatment and those in the control group,and the levels of IL-4 and IL-6 were lower;differences being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of immunoglobulin G(IgG), immunoglobulin M(IgM) and immunoglobulin A(IgA) between the two groups(P>0.05). After treatment,the levels of IgG and IgM in the control group were increased when compared with those before treatment,and the levels of IgG,IgM and IgA in the observation group were higher than those before treatment and those in the control group,differences being significant(P<0.05). Conclusion:Huangqin tang combined with chemotherapy has significant clinical effect in treating colon cancer, which can effectively improve T lymphocytes and immune function,relieve the inflammation response and enhance the level of immunoglobulin.