慢性前列腺炎/慢性盆腔疼痛综合征实验室诊断特殊生物标志物的研究进展

Advances in the studies of special biomarkers for the experimental diagnosis of CP/CPPS

对于慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的实验诊断目前还没有广为接受的特异性生物标志物,但近年来的相关研究表明,前列腺按摩液(EPS)/精液、尿液、血液/血清中存在许多相关生物标志物,其中EPS中的单核细胞趋化因子-1(CCL-2/MCP-1)、巨噬细胞炎性蛋白-1α(CCL-3/MIP-1α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、神经生长因子(NGF)、共刺激分子B7-H3,尿液中的前列腺外泄蛋白(PSEP),血清中前列腺特异性抗原(PSA)、平均血小板体积(MPV)、巨噬细胞移动抑制因子(MIF)等具有一定的临床和研究价值,并可望成为CP/CPPS实验室诊断的重要生物标志物,本文对其进行系统介绍。

At present,there are no widely accepted specific biomarkers for the experimental diagnosis of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS).Recent studies show that many related biomarkers exist in expressed prostatic secretions(EPS)or semen,urine and blood or serum.The monocyte chemotactic protein-1(MCP-1/CCL-2),macrophage-inflammatory-protein-1 alpha(MIP-1α/CCL-3),interleukin-6(IL-6),interleukin-8(IL-8),nerve growth factor(NGF)and B7-H3 in EPS,prostatic exosomal protein(PSEP)in the urine,and prostate-specific antigen(PSA),mean platelet volume(MPV)and macrophage migration inhibitory factor(MIF)in the serum are believed to be of significant clinical and research value,and expected to become important laboratory biomarkers for the diagnosis of CP/CPPS.