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口服氟嘧啶与静脉注射5-氟尿嘧啶治疗晚期结直肠癌患者的效果

Effect of Oral Fluoropyrimidine and Intravenous Injection of 5-fluorouracil in the Treatment of Advanced Colorectal Cancer
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摘要 目的探讨口服氟嘧啶与静脉注射5-氟尿嘧啶(5-FU)治疗晚期结直肠癌患者的效果及安全性。方法收集2015年1月至2017年5月凤城中心医院收治的150例晚期结直肠癌患者,根据其在住院期间选择的治疗药物分为试验组和对照组。试验组采用口服氟嘧啶(S-1或卡培他滨)治疗,对照组采用静脉注射5-FU治疗。比较两组患者的治疗效果、无进展生存期、总生存情况及不良反应发生情况。结果两组治疗有效率、疾病控制率、无进展生存期及总生存率比较,差异无统计学意义(P>0.05)。试验组3~4级腹泻、手足综合征及厌食症发生率明显高于对照组(P<0.05);对照组3~4级口腔炎、中性粒细胞及血小板减少发生率明显高于试验组(P<0.05)。结论与静脉注射5-FU相比,口服氟嘧啶显示出相同的疗效和相似的生存情况,但不良反应不同。因此,可将其作为治疗晚期结直肠癌患者的替代方案。 Objective To investigate the efficacy and safety of oral fluoropyrimidine in the treatment of advanced colorectal cancer compared with 5-fluorouracil(5-Fu)infusion.Methods A collection of 150 patients with advanced colorectal cancer admitted to Fengcheng Central Hospital from January 2015 to May 2017 were divided into experimental group and control group according to the treatment drugs selected during their hospitalization.The experimental group was treated with oral fluorouracil(s-1 or capecitabine),while the control group was treated with injection of 5-Fu.The efficacy,progression-free survival,overall survival rate and adverse reactions of the two groups were compared.Results There was no significant difference in treatment efficiency,disease control rate,progression-free survival and overall survival between the experimental group and the control group(P>0.05).The incidence of grade 3-4 hand-foot syndrome,diarrhea and anorexia of the experimental group was significantly higher than that of the control group(P<0.05).The incidence of grade 3-4 neutropenia,thrombocytopenia and stomatitis in the control group was significantly higher than that of the experimental group(P<0.05).Conclusion Oral fluoropyrimidine shows the same efficacy and similar survival outcomes as intravenous 5-Fu,but with dif ferent toxicity.Therefore,it would be an alternative to the treatment of advan ced colorectal cancer.
作者 王作鑫 WANG Zuoxin(Department of General Surgery,Fengcheng Central Hospital,Dandong 118100,China)
出处 《中国医药指南》 2020年第25期35-37,共3页 Guide of China Medicine
关键词 结直肠癌 口服 静脉注射 氟嘧啶 5-氟尿嘧啶 Colorectal cancer Oral Intravenous injection Fluoropyrimidine 5-fluorouracil
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