子宫内膜异位症患者卵泡液蛋白质组学研究进展

Progress in proteomics of follicular fluid in endometriosis patients

子宫内膜异位症是一种影响育龄妇女并可能导致不孕的慢性妇科疾病。随着医学技术的进步,关于子宫内膜异位症的研究日益增多,但目前可用于评估该疾病的技术方法缺乏敏感度、特异度和准确性,因此在诊断和治疗方面仍然面临困难。蛋白质组学不仅可以从生理、病理学角度研究疾病,而且对于认识疾病发展过程中所涉及的不同蛋白质及其变化有重要的意义。卵泡液是人体中由卵母细胞、颗粒细胞和卵泡膜细胞等产生的含有多种蛋白质的一种重要分泌物,因此本综述从对卵泡液中蛋白质组学的研究来概述子宫内膜异位症的研究进展。

Endometriosis is a chronic gynecological disease that affects women of childbearing age and may lead to infertility.With the progress of medical technology,there are more and more studies on endometriosis,but the technical methods that can be used to evaluate the disease are lack of sensitivity,specificity and accuracy,so they still face difficulties in diagnosis and treatment.Proteomics can not only study diseases from the perspective of physiology and pathology,but also play an important role in understanding the different proteins involved in the development of diseases and their changes.Follicular fluid is an important secretion containing many kinds of proteins produced by oocytes,granulosa cells and theca cells in human body.Therefore,this review summarizes the research progress of endometriosis from the study of proteomics in follicular fluid.