可手术非小细胞肺癌患者术前血浆中VEGF/sVEGFR-1比值与长期生存关系的初步探索

The Preliminary Study of Preoperational Plasma VEGF/sVEGFR-1 Ratio Significance in Operable Non-small Cell Lung Cancer

目的检测可手术非小细胞肺癌患者术前血浆中VEGF、sVEGFR-1的表达水平,并分析其与临床病理资料和长期生存的关系。方法收集98例可手术非小细胞肺癌患者术前静脉血,用ELISA方法检测血浆中VEGF和sVEGFR-1的表达水平,并分析其表达水平与患者临床病理资料和长期生存之间的关系。结果可手术非小细胞肺癌患者术前血浆中VEGF、sVEGFR-1的表达水平与患者的临床病理资料没有相关性,但是多因素生存分析中,年龄、TNM分期和VEGF/sVEGFR-1比值是可手术非小细胞肺癌患者长期生存的独立预后因子。结论血浆VEGF/sVEGFR-1比值与可手术非小细胞肺癌患者的长期生存相关,该比值在非小细胞肺癌的意义值得进一步深人研究。

Objective To evaluate the preoperational plasma level of VEGF and sVEGFR-1 in operable non-small lung cancer(NSCLC)patients,and then explore their prognostic significance.Methods We examincd prcoperational plasma level of VEGF and sVEGFR-1 of 98 operable NSCLC patients by commercially available enzyme-link immunosorbent assay(ELISA).Correlation between these values and clinical factors of these patients,including histopathological features and overall survival,was analyzed.Results Neither the preoperational level of VEGF nor sVEGFR1 was correlated with any clinical factors.In univariate and multivariate survival analysis,age,pTNM stage and the VEGF/sVEGFr-1 ratio were independent predictors for operable NSCLC patients'survival(HR=1.347,95%CI:1.068~I.699).Conclusion Preoperational plasma VEGF/sVEGFR-1 ratio was an independent predictor of poor survival of patients in opcrable NSCLC.Its signif.cance should be considcred in operable NSCLC patients.