克拉霉素联合质子泵抑制剂治疗幽门螺杆菌阳性胃溃疡的效果观察

Observation of Effect of Clarithromycin Combined with Proton Pump Inhibitor in the Treatment of Helicobacter Pylori Positive Gastric Ulcer

目的:观察幽门螺杆菌(Hp)阳性胃溃疡克拉霉素联合质子泵抑制剂治疗的效果。方法:回顾性选取2019年1月-2020年1月本院Hp阳性胃溃疡患者400例,依据治疗方法分为克拉霉素、阿莫西林联合质子泵抑制剂雷贝拉唑治疗组(雷贝拉唑组,n=200)和克拉霉素、阿莫西林联合质子泵抑制剂奥美拉唑治疗组(奥美拉唑组,n=200)两组,统计分析两组患者的临床症状评分、Hp根除情况、不良反应发生情况、临床疗效。结果:雷贝拉唑组患者治疗后较治疗前的腹痛、腹胀、反酸评分降低幅度均显著高于奥美拉唑组(P<0.05)。在Hp根除率方面,雷贝拉唑组为94.5%(189/200),奥美拉唑组为88.5%(177/200),前者显著高于后者(P<0.05)。在不良反应发生率方面,雷贝拉唑组为3.5%(7/200),奥美拉唑组为9.0%(18/200),前者显著低于后者(P<0.05)。在治疗的总有效率方面,雷贝拉唑组为95.0%(190/200),奥美拉唑组为76.0%(152/200),前者显著高于后者(P<0.05)。结论:幽门螺杆菌(Hp)阳性胃溃疡克拉霉素、阿莫西林联合质子泵抑制剂雷贝拉唑治疗的效果较奥美拉唑优。

Objective:To observe the effect of Clarithromycin combined with proton pump inhibitor in the treatment of Helicobacter pylori (Hp) positive gastric ulcer.Method:A total of 400 cases of Hp positive gastric ulcer patients in our hospital from January 2019 to January 2020 were retrospectively selected and divided into Clarithromycin,Amoxicillin combined with proton pump inhibitor Rabeprazole treatment group (Rabeprazole group,n=200),and Clarithromycin,Amoxicillin combined with proton pump inhibitor Omeprazole treatment group (Omeprazole group,n=200).The clinical symptom scores,Hp eradications,adverse reactions and clinical efficacy of the two groups were statistically analyzed.Result:The decreases of scores of abdominal pain,abdominal distension and acid regurgitation of the Rabeprazole group were significantly higher than the Omeprazole group (P<0.05).In terms of Hp eradication rate,the Rabeprazole group was 94.5% (189/200),the Omeprazole group was 88.5% (177/200),the former was significantly higher than the latter (P<0.05).In terms of incidence of adverse reactions,the Rabeprazole group was 3.5% (7/200),the Omeprazole group was 9.0% (18/200),the former was significantly lower than the latter (P<0.05).In terms of total effective rate,the Rabeprazole group was 95.0% (190/ 200),the Omeprazole group was 76.0% (152/200),the former was significantly higher than the latter (P<0.05).Conclusion:The effect of Clarithromycin,Amoxicillin combined with proton pump inhibitor Rabeprazole is better than Omeprazole in the treatment of Helicobacter pylori (Hp) positive gastric ulcer.