进行性核上性麻痹1例报道及其诊治现状

A case of progressive supranuclear palsy and the current situation of diagnosis and treatment

进行性核上性麻痹(Progressive supranuclear palsy,PSP)是一种少见的神经变性疾病,以眼球运动障碍、姿势不稳、运动障碍以及认知功能障碍为核心临床特征。该病起病隐匿,缺乏特异性的辅助检查手段,临床上诊断和鉴别困难。本文介绍1例PSP患者的诊断和治疗过程,及PSP最新诊断和治疗,以帮助临床医师提升对该病发生机制和临床诊治的认识。

Progressive supranuclear palsy(PSP)is a rare neurodegenerative disorder of the central nervous system clinically characterized by ocular motor dysfunction,postural instability,akinesia,and cognitive dysfunction.It is difficult to diagnosis and distinguish PSP from other neurodegenerative disorders because of the insidious onset and lack of sensitive and specific biomarkers at early stage of PSP.In this paper,we present a case of PSP and review the progress in the diagnosis and therapeutic approaches of this disease,which is helpful for enhancing clinicians’understanding of the disease and improving the accuracy of the clinical diagnosis of PSP.