NSCLC患者血清CCL-20、TK1水平与根治性手术后复发、转移的关系

Relationship between Serum Levels of CCL-20 and TK1 and Recurrence and Metastasis after Radical Surgery in Patients with NSCLC

目的探讨非小细胞肺癌(NSCLC)患者血清趋化因子CCL-20、胸苷激酶(TK1)与根治性手术后早期复发、转移的关系。方法选取实施肺癌根治性手术的NSCLC患者109例,根据随访2年内患者出现复发或者转移情况分为复发组50例、未复发或转移的患者(对照组)59例。对比2组术前、术后1个月、术后3个月血清CCL-20、TK1水平,并采用Logistic多因素分析法分析血清CCL-20、TK1水平与NSCLC术后复发转移的关系。结果复发组和对照组在术前的血清CCL-20、TK1水平差异无统计学意义(P>0.05),复发组术后1个月、3个月的血清CCL-20、TK1水平高于对照组(P<0.05)。TNM分期增加、低分化、术前发生淋巴结转移、术后3个月的CCL-20、TK1水平增高、术后未行辅助性化疗是NSCLC患者术后复发或转移的独立危险因素(P<0.05)。结论检测NSCLC患者术后CCL-20、TK1水平对于评估患者术后复发、转移具有一定的价值。

Objective The relationship between serum chemokine CCL-20,thymidine kinase(TK1)and early recurrence and metastasis after radical surgery in patients with non-small cell lung cancer(NSCLC).Methods 109 patients with NSCLC who underwent radical surgery for lung cancer were selected.According to the recurrence or metastasis within 2 years of follow-up,50 patients with recurrence and 50 patients without recurrence or metastasis were selected as the control group.Serum CCL-20 and TK1 levels were compared before operation,1 month after operation and 3 months after operation.Logistic multivariate analysis was used to analyze the relationship between serum CCL-20 and TK1 levels and recurrence and metastasis after NSCLC.Results There were no significant differences in serum CCL-20 and TK1 levels between the recurrent and control groups(P>0.05).The serum CCL-20 and TK1 levels in the recurrent group were higher than those in the control group at 1 month and 3 months after operation.(P<0.05);the proportion of stageⅢpatients with TNM stage,poorly differentiated tumor differentiation,lymph node metastasis,and postoperative chemotherapy were lower in the recurrent group than in the control group,and the difference was statistically significant(P<0.05);increased TNM staging,poor differentiation,preoperative lymph node metastasis,increased CCL-20,TK1 levels at 3 months postoperatively,and no adjuvant chemotherapy after surgery were independent risk factors for recurrence or metastasis in patients with NSCLC(P<0.05).Conclusion The detection of postoperative CCL-20 and TK1 levels in patients with NSCLC has certain value in evaluating patients with recurrence and metastasis.