酮洛芬注射液对靶动物奶牛的安全性研究

Study on the Target Animal Safety of Ketoprofen Injection on Dairy Cattle

为研究酮洛芬注射液对靶动物奶牛的安全性,选择20头健康泌乳奶牛,随机分成4组,即1倍(3 mg/kg·bw)、3倍(9 mg/kg·bw)、5倍(15 mg/kg·bw)推荐剂量组和空白对照组(生理盐水)。采用肌肉注射给药每日1次,连续给药9 d,观察用药后奶牛的健康状况、直肠温度等临床症状,并进行血常规、血清生化指标的测定。结果显示,使用推荐剂量(3 mg/kg·bw)至5倍推荐剂量(15 mg/kg·bw)的酮洛芬注射液,整个试验期间受试牛临床观察未发现明显的不良反应,血常规、血清生化指标检测结果均在正常范围内,表明酮洛芬注射液在临床上用于靶动物奶牛是安全的。

To evaluate the safety of ketoprofen injection on target animal dairy cattles,20 healthy lactating dairy cattles were randomly divided into 4 groups,including the control group(saline injection),the recommended dosage(3 mg/kg·bw)group,three times of recommended dosage(9 mg/kg·bw)group and five times of recommended dosage(15 mg/kg·bw)group.Each group was treated once a day by intramuscular injection for nine days.During the experiment,health condition,rectal temperature,local reaction of the udder,hematology and serum chemistries of the dairy cattles were observed and measured.The results showed that the indicators of all dairy cattles were within the normal range,and the indicators had no significant differences.the hematology and serum chemistry index had no diffrences in ketoprofen injection treatment groups when compared with the control group.Our study suggests that ketoprofen injection is safe for dairy cattles at the recommended maximum dosage.