原发性肝癌患者TSGF、GP73水平与预后关系的研究

The Relationship between TSGF and GP73 Levels and the Prognosis of Patients in Primary Hepatic Cancer

目的探讨原发性肝癌(PHC)患者肿瘤特异性生长因子(TSGF)和高尔基糖蛋白-73(GP73)水平与预后的关系。方法收集78例PHC患者(PHC组)和45例肝硬化患者(肝硬化组)、35名健康志愿者(健康组)临床资料,比较三组血清TSGF、GP73水平,随访PHC患者治疗后3年总生存率,分析PHC患者预后的影响因素以及血清TSGF、GP73水平与PHC患者预后的相关性。结果三组血清TSGF、GP73水平依次明显降低(P<0.05);术后3年共58例生存(总生存率74.36%);存活组分化程度为高分化、临床分期为Ⅰ期、淋巴结无转移、手术切缘为宽切缘、单发瘤灶占比明显高于死亡组,而微血管无侵犯分级、血清TSGF、GP73水平明显低于死亡组(P<0.05)。二元Logistic回归分析提示,淋巴结转移、微血管侵犯、血清TSGF、GP73水平是PHC患者预后的重要影响因素(P<0.05),PHC患者血清TSGF、GP73水平与预后呈明显负相关(P<0.05)。结论PHC患者血清TSGF、GP73水平与预后呈明显负相关,临床严密监测PHC患者术前血清TSGF、GP73水平或可为早期预后评估提供参考。

Objective To investigate the impact of tumor-specifi c growth factor(TSGF)and Golgi glycoprotein-73(GP73)levels onthe prognosis of patients with primary hepatic cancer(PHC).Methods The clinical data of 78 patients with PHC(PHCgroup),45 patients with liver cirrhosis(liver cirrhosis group)and 35 healthy volunteers(healthy group)were collected.Levels of TSGF and GP73 in the three groups were compared.Patients with PHC were followed up and the 3-year overall survival rate after treatment was recorded.Factors infl uencing the prognosis of patients with PHC,the correlation between TSGF and GP73 levels and the prognosis of patients with PHC were analyzed.Results Serum TSGF and GP73 levels in the three groups decreased in order(P<0.05).58 out of the 78 patients with PHC survived in 3 years after surgery,with an overall survival rate of 74.36%.The proportions of high differentiation,clinical stage I,non-lymph node metastasis,wide surgical margins and single tumor in the survival group were signifi cantly higher than those in the death group,while the grade of non-microvascular invasion,serum TSGF and GP73 levels were signifi cantly lower than those in the death group(P<0.05).Binary Logistic regression analysis showed that lymph node metastasis,microvascular invasion,serum TSGF and GP73 levels were infl uence factors of the prognosis of patients with PHC(P<0.05).Correlation analysis showed that serum TSGF and GP73 levels in patients with PHC were signifi cantly negatively correlated with the survival(P<0.05).Conclusion Serum TSGF and GP73 levels in patients with PHC are signifi cantly negatively correlated with the prognosis.Closely monitoring serum TSGF and GP73 levels in patients with PHC before surgery may provide reference for early prognosis evaluation.