老年人BMI变化对非酒精性脂肪性肝病发病的影响研究

Research on the Elderly Body Mass Index Change Effect on the Pathogenesis of Nonalcoholic Fatty Liver Disease

目的探讨老年人体质指数(BMI)变化对非酒精性脂肪性肝病(NAFLD)发病的影响。方法选取2016-2019年在上海市浦东新区曹路社区卫生服务中心参加老年体检的本地居民,比较4年间BMI变化下的NAFLD发病率,采用logistic回归模型分析BMI变化与老年人NAFLD的相关性。结果通过分析3 297名老年人4年间BMI变化发现,随着基线BMI增加,随访过程中NAFLD的发生概率越大,组间差异有统计学意义。与随访过程中BMI保持正常相比,发展为NAFLD的危险性由高到低依次为超重转为肥胖组、保持肥胖组、肥胖转为超重组、正常转为肥胖组、正常转为超重组和保持超重组。而偏瘦转为正常组和保持偏瘦组NAFLD的发生危险性低。结论老年人BMI变化与NAFLD的发病相关,控制体重可以降低老年人NAFLD发病率。

OBJECTIVE To study the affect of elder people body mass index(BMI) change on the impact of nonalcoholic fatty liver disease. METHODS It selected the elder people who had taken physical examination uninterruptedly in Caolu Community of Shanghai from 2016 to 2019, to compare the rate of non-alcoholic fatty liver under different BMI changers in the four years and study the correlations between BMI changers and non-alcoholic fatty liver by way of logistic regression model analysis. RESULTS By analyzing the BMI changes of 3 297 old people in 4 years, there were higher the nonalcoholic fatty liver disease in elderly patients in follow-up visit with the increase of baseline weight. Nonalcoholic fatty liver disease incidence was compared among each group, and differences were statistically significant. Compared with normal weight during the follow-up visit, the occurrence risk of nonalcoholic fatty liver disease from high to low was overweight may develop into obesity group, keep the obesity group, obesity becomes overweight group,normal to obesity group, normal to overweight group, and maintain overweight group. The lean into normal group and maintain lean group suggested that nonalcoholic fatty liver disease risk was lower. CONCLUSION The elderly BMI change was closely related to the incidence of nonalcoholic fatty liver disease. Weight control could reduce the incidence of nonalcoholic fatty liver disease in the elderly.