阿奇霉素联合维生素A及甘草锌颗粒治疗肺炎支原体肺炎患儿的疗效分析

The rapeutic effect of azithromycin combined with vitamin A and glycyrrhiza zinc granules on children with mycoplasma pneumoniae pneumonia

目的:观察阿奇霉素联合维生素A(Vit A)与甘草锌颗粒治疗肺炎支原体肺炎(MPP)患儿的临床疗效,及其对患儿血清中丙二醛(MDA)及免疫球蛋白(Ig)水平的影响。方法:选取2017-08—2018-08治疗的MPP患儿102例,按照随机数字表法分为对照组和观察组,每组51例。对照组患儿给予口服阿奇霉素干混悬剂,观察组在对照组基础上给予Vit A及甘草锌颗粒。比较2组患儿的疗效、白介素-6(IL-6)、白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)、Vit A、锌(Zn)、MDA、IgA、IgG、IgM及不良反应发生率。结果:观察组的有效率为96.08%,明显高于对照组的84.31%(P<0.05)。治疗前,2组患儿TNF-α、IL-8、IL-6、Vit A、Zn、MDA、IgM、IgG、IgA水平差异无统计学意义(P>0.05)。治疗2周后,观察组的IgM、IgG、IgA、MDA、TNF-α、IL-8、IL-6水平均低于对照组(P<0.05)。观察组的Vit A及Zn高于对照组(P<0.05)。2组患儿不良反应发生率差异无统计学意义(P>0.05)。结论:采用阿奇霉素联合Vit A与甘草锌颗粒治疗MPP患儿具有良好的临床疗效,可显著减轻患者体内的氧化反应,降低患者的炎症反应,调节机体的免疫功能,且安全性高。

Objective:To observe the clinical effect of azithromycin combined with vitamin A(Vit A)and glycyrrhiza zinc granule in the treatment of children with mycoplasma pneumoniae pneumonia(MPP)and its effect on the serum levels of malondialdehyde(MDA)and immunoglobulin(Ig)of children with MPP. Method:From August 2017 to August 2018,102 children with MPP were randomly divided into control group(n=51)and observation group(n=51).In the control group,the oral azithromycin dry suspension was given,which was on the basis of Vit A and zinc licorice particles of the control group.The efficacy,interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α),Vit A,zinc(Zn),MDA,IgA,IgG,IgM and the incidence of adverse events were observed in the two groups. Result:The effective rate of the observation group was 96.08%,which was significantly higher than that of the control group(84.31%)(P<0.05).Before treatment,there was no difference in TNF-α,IL-8,IL-6,Vit A,Zn,MDA,IgM,IgG and IgA levels between the two groups(P>0.05).After 2 weeks of treatment,the levels of IgM,IgG,IgA,MDA,TNF-α,IL-8 and IL-6 in the observation group were lower than those the control group(P<0.05).Vit A and Zn in the observation group were higher than those of the control group(P<0.05).There was no difference in the incidence of adverse events between the two groups(P>0.05).Conclusion:Azithromycin combined with Vit A and glycyrrhiza zinc granules may have good clinical efficacy in treating children with MPP.It can significantly reduce the oxidation reaction in patients with MPP,reduce the inflammatory reaction of patients,regulate the immune function of the body,and be of high safety.