红细胞血型Indian抗原研究进展

Research progress of Indian antigen of erythrocyte blood group

Indian血型抗原最初1970年发现于一个印度孟买人的血浆中,先发现了抗Ina抗体,而确认了Ina抗原的存在后,又发现了Inb抗原。1973年国际输血协会(ISBT)确认了这是一个独立的红细胞系统抗原,并命名为Indian抗原,抗原的简称是IN,系统编号是023。2018年ISBT最新确认这个系统有6个抗原,其中高频抗原5个,低频抗原1个,并且还确认了抗原详细的基因位点和外显子系列、以及抗原相关的分子生物学概念。

The IN antigen is an antigen of the erythrocyte system,which has six antigens confirmed at present.Seventeen new exons were identified.The gene encoding product was adhesion molecule glycoprotein 44 and membrane differentiation antigen CD44.It can cause transfusion hemolysis and is an antigen of clinical significance.In antigen is one of the components of cytoskeleton protein,which participates in the formation of pseudopodia and cell migration.It has the function of adhesion of immune cells to tumor cells and is related to tumor metastasis.